王岚,马玉良,王伟民,朱天刚,靳文英,赵红,曹成富,张前,王静

• 1:北京大学人民医院心血管内科急性心肌梗死早期预警和干预北京市重点实验室心血管转化医学研究中心

摘要(Abstract)：

目的应用心肌声学造影(MCE)评估急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)后冠状动脉微循环障碍(CMD)的发生情况,并探讨其对心功能的影响。方法入选2016年6月至2021年5月北京大学人民医院因STEMI住院行PCI,并于住院期间完成MCE的患者109例。根据MCE检查分为CMD组及微循环功能正常组。分析两组患者的一般临床资料、STEMI相关临床情况、冠状动脉造影及血运重建情况以及MCE资料。结果 109例STEMI患者中CMD发生率为66.1%。CMD组患者与正常组相比C反应蛋白水平更高[10.0(1.3,46.2)mg/L比1.7(0.5,15.5)mg/L,P=0.029],脑钠肽水平更高[333(100,685)pg/ml比125(39,348)pg/ml,P=0.016],左心室射血分数(LVEF)更低[51.0%(43.1%,58.9%)比58.9%(51.5%,63.8%),P=0.002],左心室整体长轴应变更差[–10.8%(–8.1%,–13.6%)比–13.3%(–10.5%,–16.7%),P=0.006],节段性室壁运动异常(RWMA)比例更高(95.8%比78.4%,P=0.004),室壁运动评分指数(WMSI)更差[1.53(1.37,1.88)比1.29(1.09,1.47),P<0.001],室壁瘤发生率更高(19.4%比0,P=0.004)。且校正罪犯血管的影响后,两组患者LVEF、RWMA比例及WMSI依旧差异有统计学意义(均P<0.05)。结论与微循环功能正常组相比,STEMI后出现CMD的患者具有更高的炎性水平,室壁运动及心功能相对更差,提示不良预后。

关键词(KeyWords)： ST段抬高型心肌梗死;心肌声学造影;冠状动脉微循环障碍;心功能

Abstract:

Keywords:

基金项目(Foundation): 首都卫生发展科研专项项目（新）（首发2020-1-4031）

作者(Author): 王岚,马玉良,王伟民,朱天刚,靳文英,赵红,曹成富,张前,王静

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