经皮冠状动脉介入治疗患者二级预防的性别差异分析Gerder differences of coronary heart disease secondary prevention in patients post percutaneous coronary intervention
韩晓宁,蒋捷,张岩,于荣辉,龚艳君,洪涛,霍勇
摘要(Abstract):
目的在已经接受经皮冠状动脉介入治疗(PCI)的冠状动脉粥样硬化性心脏病(冠心病)患者中,了解二级预防治疗现状的性别差异。方法对31家三级甲等医院中至少有一次PCI史的门诊或住院冠心病患者进行病史采集和实验室检查,比较不同性别患者在戒烟、控制体重、血压、血脂以及药物治疗等各方面的差异。结果 4532例患者中,女性1151例,占全部PCI患者的25.4%。女性患者有吸烟史的比例明显低于男性患者,但戒烟比例与男性患者差异无统计学意义[52.1%(98例)比51.0%(1344例),P=0.849]。男性患者的平均体重指数、平均腰围和超重比例均大于女性患者(P=0.000),但女性的腰围不达标比例高于男性(59.2%比42.2%,P=0.000)。女性患者合并高血压、高脂血症和糖尿病的比例均高于男性,差异具有统计学意义(P=0.000)。且女性患者血压、血脂和血糖的控制达标比例均低于男性患者,分别为[血压:65.4%比73.1%,P=0.000;低密度脂蛋白胆固醇(LDL-C):45.2%比54.7%,P=0.000;空腹血糖:52.7%比58.8%,P=0.000]。不同性别患者二级预防药物使用率差异无统计学意义。结论接受PCI的女性冠心病患者合并冠心病危险因素多于男性,而除戒烟和体重控制外,各项危险因素控制达标率均低于男性,女性患者二级预防用药水平与男性相当。
关键词(KeyWords): 冠心病;介入治疗;二级预防;性别
基金项目(Foundation): “十一五”国家科技支撑计划课题(2006BAI01A02)
作者(Author): 韩晓宁,蒋捷,张岩,于荣辉,龚艳君,洪涛,霍勇
参考文献(References):
- [1]Mosca L,Appel LJ,Benjamin EJ,et al.Evidence-based guidelines for cardiovascular disease prevention in women.Circulation,2004,109:672-693.
- [2]陈韵岱.女性冠心病特点及诊治进展现状.当代心脏病学进展,2007,10:121-123.
- [3]Mosca L,Benjamin EJ,Berra K,et al.Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update:a guideline from the American Heart Association.J Am Coll Cardiol,2011,57:1404-1423.
- [4]Melloni C,Berger JS,Wang TY,et al.Representation of women in randomized clinical trials of cardiovascular disease prevention.Circ Cardiovasc Qual Outcomes,2010,3:135-142.
- [5]Fleg JL,Forman DE,Berra K,et al.Secondary prevention of atherosclerotic cardiovascular disease in older adults a scientific statement from the american heart association.Circulation,2013,128:2422-2446.
- [6]Mosca L,Christian AH,Mochari-Greenberger H,et al.A randomized clinical trial of secondary prevention among women hospitalized with coronary heart disease.J Womens Health(Larchmt),2010,19:195-202.
- [7]刘军,赵冬,刘静,等.阿司匹林在冠心病二级预防中的应用现况.中华内科杂志,2009,48:809-813.
- [8]李红娟,刘军,刘静,等.他汀类药物在中国极高危冠心病患者二级预防中的应用现况.中华心血管病杂志,2010,38:1033-1037.
- [9]Jiang J,Hong T,Yu R,et al.Knowledge of secondary prevention guidelines for coronary heart disease:results from a physicians'survey in China.Eur J Prev Cardiol,2012,19:991-998.
- [10]Bi Y,Gao R,Patel A,et al.Evidence-based medication use among Chinese patients with acute coronary syndromes at the time of hospital discharge and 1 year after hospitalization:results from the Clinical Pathways for Acute Coronary Syndromes in China(CPACS)study.Am Heart J,2009,157:509-516.