血清肌钙蛋白Ⅰ水平与不稳定性心绞痛患者预后的关系Relationship between serum cardiac troponin I levels and risk of subseqent heart events in unstable angina
贾永平,张寄南,马文珠,曹克将,杨志健,马根山,朱铁兵,徐晋丹
摘要(Abstract)：
目的 探讨肌钙蛋白Ⅰ对不稳定性心绞痛 (UA)微小心肌损伤的判断价值以及对其预后的价值。方法 对 10 6例UA和 44例稳定性心绞痛 (SA)患者、6 8例冠状动脉造影正常者及 72例健康者进行血清心肌肌钙蛋白Ⅰ (cTnⅠ )及肌酸激酶同工酶 (CK MB)测定 ,部分患者测定血清心肌肌钙蛋白T(cTnT) ,观察住院及出院后 90～ 45 0d心脏事件发生率 ,用Logistic单因素和多因素回归分析 2 3个可能危险因素。结果 6 1例UA患者血清cTnⅠ增高 (5 7 5 % ) ,而SA患者只 8例增高 (18 18% ) ,血清cTnⅠ增高者发生心脏事件者明显高于cTnⅠ正常者 (P <0 0 0 1) ,血清cTnⅠ水平越高 ,心脏事件发生率越高 ;血清cTnⅠ水平与心绞痛严重程度密切相关 (r =0 5 3,P <0 0 0 1) ;cTnT检出心肌微小损伤及预测预后与cTnⅠ有相似的作用。结论 cTnⅠ是判断心肌细胞微小损伤的敏感和特异性指标 ,cTnⅠ增高可作为UA患者发生心脏事件的预测指标之一
关键词(KeyWords)： 肌钙蛋白;心绞痛,不稳定性;预后
基金项目(Foundation): 国家“九五”攻关课题 (BS970 2 8);; 江苏省卫生厅部分基金资助
作者(Author): 贾永平,张寄南,马文珠,曹克将,杨志健,马根山,朱铁兵,徐晋丹
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