氨吡酮对离体灌流鼠心收缩与舒张功能的作用
马业新,陆再英,赵华月
摘要(Abstract)：
在离体等容收缩与舒张的灌流鼠心,观察了氨吡酮对心脏收缩与舒张功能的作用.结果表明,低浓度氨吡酮(Inmol/L,100nmol/L)不能明显增加左室发生压(LVDP)、最大左室压力上升速度(dp/dt max)及下降速度(-dp/dt max),也不能明显缩短时间常数(t);高浓度氨吡酮(1μmol/L明显降低了LVDP(p<0.01)、dp/dt max(p<0.01)、-dp/dt max(p<0.01),并且显著地延长了t值(p<0.05).此表明、氨吡酮并无直接的正性肌力与改善舒张功能的作用,相反,高浓度时反抑制心脏的收缩与舒张功能.
关键词(KeyWords)： 氨吡酮;收缩功能;舒张功能
基金项目(Foundation):
作者(Author): 马业新,陆再英,赵华月
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