马会利,刘鸣,孙爱军,陈纪林,王颖,王箴,王克强,黄薇,邹云增,葛均波

• 1:复旦大学附属中山医院上海市心血管病研究所
• 2:人民解放军第二炮兵总医院心内科
• 3:中国医学科学院阜外心血管病研究所
• 4:中国南方基因组研究中心

摘要(Abstract)：

目的研究中国人群中纤维蛋白原βG-455A基因多态性与血浆纤维蛋白原水平及冠心病亚型的关系。方法1 485例因胸痛或非侵入性检查提示心肌缺血的成年人进行了冠状动脉造影检查,根据临床表现及冠状动脉造影结果被分为冠心病组(n=1 019)及对照组(n=466),冠心病组又被分为稳定型心绞痛(SAP)组(n=674)及急性冠状动脉综合征(ACS)组(n=345)。应用vonClauss法测定血浆纤维蛋白原水平,多聚酶链反应(PCR)和HaeⅢ内切酶技术检测纤维蛋白原βG-455A基因多态性。结果ACS组及SAP组的血浆纤维蛋白原水平较对照组显著升高,其中ACS组最高(ACS组380.92±92.35 mg/dL,SAP组352.49±94.89 mg/dL,对照组311.72±87.09 mg/dL,三组之间两两比较,P均<0.001)。在对照组及SAP组中基因型为AA的纯合子其血浆纤维蛋白原水平较携带G等位基因的个体为高(对照组AA为363.83±76.66 mg/dL,与GA的337.83±77.43mg/dL或GG的295.28±88.06 mg/dL比较,P均<0.05;SAP组AA为429.82±93.35 mg/dL,与GA的368.30±90.39 mg/dL或GG的337.89±94.32 mg/dL比较,P均<0.05),而在ACS组未见此趋势。各组之间的基因型及等位基因频率分布差异无统计学意义(P>0.05),-455A等位基因与冠心病发病风险无相关性。结论血浆纤维蛋白原水平升高与冠心病发病风险相关。纤维蛋白原βG-455A基因多态性与冠心病发病无相关性。

关键词(KeyWords)： 等位基因;纤维蛋白原;冠状动脉疾病;心绞痛

Abstract:

Keywords:

基金项目(Foundation): 863计划(2006AA02A406)冠心病的分子分型及个体化治疗研究;; 973计划(2006CB503803)重大血管性疾病发病机制和防治的基础研究

作者(Author): 马会利,刘鸣,孙爱军,陈纪林,王颖,王箴,王克强,黄薇,邹云增,葛均波

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