钆对比剂联合血管内超声为碘对比剂严重过敏患者成功完成经皮冠状动脉介入治疗1例A case of Gadolinium-based contrast agent combined with intravascular ultrasound for successful percutaneous coronary intervention in a patient with severe allergy to iodine contrast agent
刘新,王志远,刘国晖,曾红,李相冬
摘要(Abstract):
使用碘对比剂的传统X线冠状动脉造影是诊断冠状动脉疾病和确定治疗策略[包括经皮冠状动脉介入治疗(PCI)]的金标准技术。然而,对碘对比剂严重过敏和肾功能不全以及严重甲状腺功能亢进的患者限制了碘对比剂的使用,尤其在面临急性冠状动脉综合征需要急诊PCI时。钆对比剂主要开发用于磁共振成像,能否将其应用于冠状动脉造影,目前相关研究很少。本病例报道1例使用碘对比剂发生严重过敏反应的患者,最终通过应用钆对比剂联合血管内超声指导成功完成复杂PCI。通过该病例并回顾相关文献,为碘对比剂禁忌证患者行冠状动脉检查及治疗提供新的思路。
关键词(KeyWords): 钆对比剂;碘对比剂过敏;冠状动脉造影;经皮冠状动脉介入治疗;血管内超声
基金项目(Foundation):
作者(Author): 刘新,王志远,刘国晖,曾红,李相冬
参考文献(References):
- [1]王宁远,王威,辛倩,等.极低碘对比剂指导冠心病合并慢性肾功能不全介入治疗研究进展[J].中国介入心脏病学杂志,2024,32(4):220-223.DOI:10.3969/j.issn.1004-8812.2024.04.006.
- [2]陈怡粤,邓鸣,房子熙,等.表现为短暂性全面性遗忘的心脏造影术后碘对比剂脑病1例[J].中国介入心脏病学杂志,2023,31(5):398-400.DOI:10.3969/j.issn.1004-8812.2023.05.013.
- [3]Saleh L,Juneman E,Movahed MR.The use of gadolinium in patients with contrast allergy or renal failure requiring coronary angiography,coronary intervention,or vascular procedure[J].Catheter Cardiovasc Interv,2011,78(5):747-754.DOI:10.1002/ccd.22907.
- [4]K?lsch H,K?lsch T,Eggebrecht H,et al.Gadoliniumbased coronary angiography in patients with contraindication for iodinated X-ray contrast medium:a word of caution[J].J Interv Cardiol,2008,21(2):167-174.DOI:10.1111/j.1540-8183.2007.00340.x.
- [5]Ose K,Doue T,Zen K,et al."Gadolinium"as an alternative to iodinated contrast media for X-ray angiography in patients with severe allergy[J].Circ J,2005,69(4):507-509,DOI:10.125 3/circj.69.507.
- [6]Spinosa DJ,Angle JF,Hartwell GD,et al.Gadolinium-based contrast agents in angiography and interventional radiology[J].Radiol Clin North Am,2002,40(4):693-710.DOI:10.1016/s0033-8389(02)00022-2.
- [7]Spinosa DJ,Kaufmann JA,Hartwell GD.Gadolinium chelates in angiography and interventional radiology:a useful alternative to iodinated contrast media for angiography[J].Radiology,2002,223(2):319-325.DOI:10.1148/radiol.2232010742.
- [8]Prince MR,Arnoldus C,Frisoli JK.Nephrotoxicity of highdose gadolinium compared with iodinated contrast[J].J Magn Reson Imaging,1996,6(1):162-166.DOI:10.1002/jmri.1880060129.
- [9]Giozzet M,Cavagna E,De Dea M,et al.Gadolinium for DSA in two patients with azotemia:images of suitable quality and risk of acute renal failure[J].G Ital Nefrol,2003,20(3):298-301.
- [10]Erley CM,Bader BD,Berger ED,et al.Gadoliniumbased contrast media compared with iodinated media for digital subtraction angiography in azotaemic patients[J].Nephrol Dial Transplant,2004,19(10):2526-2531.DOI:10.1093/ndt/gfh272.
- [11]Sam AD 2nd,Morasch MD,Collins J,et al.Safety of gadolinium contrast angiography in patients with chronic renal insufficiency[J].J Vasc Surg,2003,38(2):313-318.DOI:10.1016/s0741-5214(03)00315-x,
- [12]Sayin T,Turhan S,Akyürek O,et al.Gadolinium:nonionic contrast media(1:1)coronary angiography in patients with impaired renal function[J].Angiology,2007,58(5):561-564.DOI:10.1177/0003319707303640.
- [13]Sarkis A,Badaoui G,Azar R,et al.Gadolinium-enhanced coronary angiography in patients with impaired renal function[J].Am J Cardiol,2003,91(8):974-975,A4.DOI:10.1016/s0002-9149(03)00116-4.
- [14]Tepel M,Zidek W.Acetylcysteine and contrast medianephropathy[J].Curr Opin Nephrol Hypertens,2002,11(5):503-506.DOI:10.1097/00041552-200209000-00005.
- [15]Bardin T,Richette P.Nephrogenic systemic fibrosis[J].Curr Opin Rheumatol,2010,22(1):54-58.DOI:10.1097/BOR.0b013e328333bf3d.
- [16]Kaewlai R,Abujudeh H.Nephrogenic systemic fibrosis[J].AJR Am J Roentgenol,2012,199(1):W17-W23.DOI:10.2214/AJR.11.8144.
- [17]Kribben A,Witzke O,Hillen U,et al.Nephrogenic systemic fibrosis:pathogenesis,diagnosis,and therapy[J].J Am Coll Cardiol,2009,53(18):1621-1628.DOI:10.1016/j.jacc.2008.12.061.
- [18]Mathur M,Jones JR,Weinreb JC.Gadolinium deposition and nephrogenic systemic fibrosis:a radiologist's primer[J].Radiographics,2020,40(1):153-162.DOI:10.1148/rg.2020190110.
- [19]Woolen SA,Shankar PR,Gagnier JJ,et al.Risk of nephrogenic systemic fibrosis in patients with stage 4 or 5 chronic kidney disease receiving a GroupⅡgadolinium-based contrast agent:a systematic review and meta-analysis[J].JAMA Intern Med,2020,180(2):223-230.DOI:10.1001/jamainternmed.2019.5284.
- [20]Guragai N,Roman S,Vasudev R,et al.Gadoliniumbased coronary angiography in a patient with prior known anaphylaxis to iodine-based dye[J].J Community Hosp Intern Med Perspect,2021,11(2):286-288.DOI:10.1080/20009666.2021.1890337.
- [21]胡文瑛,严鹏勇,王睿,等.“零对比剂”经皮冠状动脉介入治疗对重度肾功能不全患者的安全性及有效性分析[J].中国介入心脏病学杂志,2021,29(7):371-374.DOI:10.3969/j.issn.1004-8812.2021.07.002.
- [22]Rieger J,Sitter T,Toepfer M,et al.Gadolinium as an alternative contrast agent for diagnostic and interventional angiographic procedures in patients with impaired renal function[J].Nephrol Dial Transplant,2002,17(5):824-828.DOI:10.1093/ndt/17.5.824.
- [23]Briguori C,Colombo A,Airoldi F,et al.Gadolinium-based contrast agents and nephrotoxicity in patients undergoing coronary artery procedures[J].Catheter Cardiovasc Interv,2006,67(2):175-180.DOI:10.1002/ccd.20592.
- [24]Tajti P,Ayoub M,Nuehrenberg T,et al.Coronary physiology and percutaneous intervention managed with gadolinium road mapping and intravascular ultrasound in hyperthyroidism[J].Cardiol J,2021,28(4):642-645.DOI:10.5603/CJ.a2021.0027.
- [25]Gupta A,Neupane S,Basir M,et al.Zero-iodinated contrast retrograde percutaneous coronary interventions of chronic total occlusions using gadolinium and imaging guidance:a case report of a patient with severe anaphylaxis to iodinated contrast[J].Eur Heart J Case Rep,2020,4(3):1-7.DOI:10.1093/ehjcr/ytaa092.
- [26]Cubero-Gómez JM,Guerrero Márquez FJ,Diaz-de la-Llera L,et al.Severe thrombocytopenia induced by iodinated contrast after coronary angiography:the use of gadolinium contrast and intravascular ultrasound as an alternative to guide percutaneous coronary intervention[J].Rev Port Cardiol,2017,36(1):61.e1-61.e4.DOI:10.1016/j.repc.2016.04.014.
- [27]Juneman E,Saleh L,Thai H,et al.Successful coronary angiography with adequate image acquisition using a combination of gadolinium and a power injector in a patient with severe iodine contrast allergy[J].Exp Clin Cardiol,2012,17(1):17-19.