无需全身麻醉、经胸超声心动图引导的改良经皮左心耳封堵术的初步经验The preliminary experience of modified percutaneous left atrial appendage occlusion under transthoracic echocardiographic guidance without general anesthesia
陈良龙,陆林祥,方军,鄢晓平,黄煜,李金国,孙旭东,钟玲
摘要(Abstract):
目的初步探讨经胸超声心动图(TTE)替代经食管超声心动图(TEE)引导、无全身麻醉的改良经皮左心耳封堵术(PLAAO)的可行性及安全性。方法对14例符合入选标准的患者以TTE替代TEE引导、无全身麻醉进行PLAAO,术后定期临床随访,观察PLAAO相关主要不良事件。结果所有患者术中器械操作均获成功、无封堵相关严重并发症发生,即刻封堵成功率100%。住院及随访期间无PLAAO相关主要不良事件发生。本组14例患者改良局麻下TTE引导PLAAO患者手术时间及手术费用(不含麻醉及封堵器费用)分别为75~150(108±22)min及14601~33083(22491±5984)元。局麻患者较全身麻醉(全麻)患者每例节约麻醉费用960元。X线透视时间8~32(15.8±7.6)min。结论初步证实TTE替代TEE引导、无全身麻醉的改良PLAAO是安全有效的,这种方法简化了手术过程、有利于PLAAO的推广应用,但仍需更多病例加以验证。
关键词(KeyWords): 经皮左心耳封堵术;经胸超声心动图;全身麻醉
基金项目(Foundation): 福建省医学创新课题资助计划(2014-CX-12)
作者(Author): 陈良龙,陆林祥,方军,鄢晓平,黄煜,李金国,孙旭东,钟玲
参考文献(References):
- [1]Reddy VY,Doshi SK,Sievert H,et al.PROTECT AF investigators.percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation:2.3-year follow-up of the PROTECT AF(watchman left atrial appendage system for embolic protection in patients with atrial fibrillation)trial.Circulation,2013,127(6):720-729.
- [2]苏晞.左心耳封堵治疗的现状和进展.中国介入心脏病学杂志,2016,24(8):458-461.
- [3]Wunderlich NC,Beigel R,Swaans MJ,et al.Percutaneous interventions for left atrial appendage exclusion:options,assessment,and imaging using 2D and 3D echocardiography.JACC Cardiovasc Imaging,2015,8(4):472-488.
- [4]Lip GY,Nieuwlaat R,Pisters R,et al.Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach:the euro heart survey on atrial fibrillation.Chest,2010,137(2):263-272.
- [5]Pisters R,Lane DA,Nieuwlaat R,et al.A novel user-friendly score(HAS-BLED)to assess 1-year risk of major bleeding in patients with atrial fibrillation:the Euro Heart Survey.Chest,2010,138(5):1093-1100.
- [6]Meier B,Blaauw Y,Khattab AA,et al.Document reviewers.EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion.Europace,2014,16(10):1397-1416.
- [7]中华医学会心电生理和起搏分会,中华医学会心血管病学分会,中国医师协会心律学专业委员会.左心耳干预预防心房颤动患者血栓栓塞事件:目前的认识和建议.中国心脏起搏与心电生理杂志,2014,18(4):471-486.
- [8]M9bius-Winkler S,Majunke N,Sandri M,et al.Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device.World J Cardiol,2015,7(2):65-75.
- [9]Odell JA,Blackshear JL,Davies E,et al.Thoracoscopic obliteration of the left atrial appendage:potential for stroke reduction.Ann Thorac Surg,1996,6l:565-569.
- [10]Reddy VY,M9bius-Winkler S,Miller MA,et al.Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation:the ASAP study(ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology).J Am Coll Cardiol,2013,61(25):2551-2556.
- [11]Reddy VY,Sievert H,Halperin J,et al.PROTECT AF steering committee and investigators.Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation:a randomized clinical trial.JAMA,2014,312(19):1988-1998.
- [12]Kirchhof P,Benussi S,Kotecha D,et al.2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.Eur Heart J,2016,37(38):2893-2962.