缺血预适应对PTCA术后心肌肌钙蛋白I升高的影响Beneficial impact of preconditioning during PTCA on cardiac troponin I release
杨志健,张如升,张馥敏,朱铁兵,马文珠,曹克将,黄峻
摘要(Abstract)：
目的 用血清心肌肌钙蛋白I(cTnI)作为心肌损伤标记物评价缺血预适应 (IP)对经皮腔内冠状动脉成形术 (PTCA)心肌损伤的保护作用。方法 把 15 0例行PTCA的冠心病 (CAD)患者随机分为两组 :(1)常规手术组 (UC组 ) 12 0例 ;(2 )缺血预适应组 (设置缺血预适应手术方式 ,IP组 ) 30例。两组分别测定其术前、术后第 6、12、2 4、4 8、72小时的血清cTnI水平并进行随访 ,分析相关因素 ,比较两组间cTnI的变化及出院后发生的心脏事件。结果 UC组 12 0例患者中 2 9例术后cTnI升高 ,IP组 30例患者中 2例术后cTnI升高 ,两组cTnI升高差异有显著性 (P <0 0 5 ) ;随访发现发生的心脏事件两组间差异无显著性 (P >0 0 5 )。结论 缺血预适应对PTCA术造成的心肌损伤有保护作用 ,现尚不能肯定IP对PTCA术后患者心脏事件有影响。
关键词(KeyWords)： 缺血预处理;肌钙蛋白;血管成形术,经腔,经皮冠状动脉
基金项目(Foundation):
作者(Author): 杨志健,张如升,张馥敏,朱铁兵,马文珠,曹克将,黄峻
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