张奇,张瑞岩,胡健,杨震坤,丁风华,朱天奇,朱政斌,沈卫峰

• 1:上海交通大学医学院附属瑞金医院心脏科

摘要(Abstract)：

目的心肌梗死后左心室重构与患者的临床预后密切相关,本研究旨在探讨糖尿病对急性ST段抬高心肌梗死(STEMI)患者直接经皮冠状动脉介入治疗(PCI)后左心室重构的影响。方法单中心、前瞻性入选STEMI接受急诊PCI的患者451例,其中糖尿病患者93例,非糖尿病患者358例。比较糖尿病组与非糖尿病组患者的一般临床情况、造影和介入治疗结果、术后1周和6个月心超随访左心室重构及不良心脏事件发生率。结果与非糖尿病组比较,糖尿病组患者症状至就诊时间显著延长[(399±106)min比(321±116)min,P=0.006],多支血管病变比例增高(65.6%比51.7%,P=0.02),但两组住院期左心功能相似。PCI后6个月心超随访发现,糖尿病组患者左心室重构比例明显高于非糖尿病患者(29.0%比17.3%,P=0.01)。糖尿病(RR 2.10,95%CI 1.31-4.79,P=0.02)、前壁心肌梗死(RR 2.13,95%CI 1.31-4.19,P=0.03)及多支血管病变(RR 2.85,95%CI1.73-4.67,P=0.01)是STEMI患者发生左心室重构的独立预测因素。临床随访显示,糖尿病组患者因心力衰竭诊断而再次住院的比例增加(12.9%比8.1%,P=0.15)。左心室重构患者(23/89例)发生不良临床事件比例显著高于无左心室重构患者(25.8%比6.6%,P<0.001)。结论糖尿病是急性STEMI患者急诊PCI后发生左心室重构的高危因素,因此,制定糖尿病STEMI患者的综合干预策略,可能有助于进一步改善其预后。

关键词(KeyWords)： 心肌梗死;经皮冠状动脉介入治疗;左心室重构;糖尿病

Abstract:

Keywords:

基金项目(Foundation): 上海市科委课题(12QA1402100)

作者(Author): 张奇,张瑞岩,胡健,杨震坤,丁风华,朱天奇,朱政斌,沈卫峰

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