何攀,史杨,陈海威,杨俊杰,郭军,陈韵岱,汪奇

• 1:中国人民解放军总医院第六医学中心心血管病医学部
• 2:中国人民解放军医学院

摘要(Abstract)：

目的 探讨对比剂浓度对准分子激光消蚀斑块作用的影响。方法 采用直径为0.9mm的激光纤维导管，运用波长为308nm的氯化氙准分子激光进行斑块模型消蚀实验。在准分子激光消蚀过程中，根据所注射对比剂浓度不同分为5组：生理盐水组、25%浓度组、50%浓度组、75%浓度组、100%浓度组。通过光学相干断层成像评估准分子激光消蚀后斑块管腔面积变化，以评估对比剂浓度对准分子激光消蚀作用的影响。同时，利用水听器测量准分子激光在不同对比剂浓度的液体中产生的冲击波压力，以探讨准分子激光的冲击波压力与其消蚀作用的相关性。结果 75%浓度组和100%浓度组的消蚀面积相近（P>0.05），均大于50%浓度组、25%浓度组和生理盐水组（均P <0.001）。50%浓度组的消蚀面积显著大于25%浓度组和生理盐水组（均P<0.001），而25%浓度组则大于生理盐水组（P<0.001）。对比剂浓度对准分子激光冲击波压力的影响也呈现相似的趋势。准分子激光产生的冲击波压力与其消蚀面积之间存在显著正相关（r=0.9987,P<0.001）。结论 可以通过改变对比剂浓度来调节准分子激光对斑块组织消蚀作用的强度，为准分子激光联合对比剂注射技术在冠心病治疗中运用提供了指导。

关键词(KeyWords)： 准分子激光;对比剂注射;消蚀作用;光学相干断层成像

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 何攀,史杨,陈海威,杨俊杰,郭军,陈韵岱,汪奇

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