SIGNIFICANCE OF VENTRICULOATRIAL CONDUCTION IN PATHOGENESIS OF PACEMAKER SYNDROME AND THE INTERVENIENT STUDY OF AMIODARONESIGNIFICANCE OF VENTRICULOATRIAL CONDUCTION IN PATHOGENESIS OF PACEMAKER SYNDROME AND THE INTERVENIENT STUDY OF AMIODARONE
摘要(Abstract)：
<正> The present study is to search the significance of ventriculoa1trialconduction(VAC)in pathogenesis of pacemaker syndrome(PMS)anddetermined the act of Amiodarone on VAC,thereby looking methods forcure PMS.The twelve patients with VVI pacemaker complicated byPMS,as well as showed VAC on their electrocardingram(ECG),weresetected into our study.We measured pulmonary capillary wedge pressure(PCMP)and cardiac output(CO)by Swan-Ganz catheter before and afterAmiodaronn's intravenous injection(300rag i.v.)in the four patients of themand prescribed Amiodarone(0.2 tid;after a week,0.2q.d)for the othereight patients.The PMSpatients with VAC have a higher PCWP(mean:3.06+0.31Kpa)and a lower CO(3.13+0.19L/min).however,their PCWPsgo down 2.18+0.36 Kpa)and their COs go up(3.90+0.12 L/min)after Amiodarone's intravenous injection:The patients'symptoms disappearmainly or completely,tugather with the VACs on ECG disappear afterusing Amiodarone.The present study suggested that VAC play a key rolein pathogenesis of PMS and Amiodarone maybe applied to treat PMS bystopping VAC.Theortically,Amiodarone also maybe applied to treatpacemaker-mediated tachycardia(PMT)which result from VAC in thepatients with DDD pacemaker.
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