慢性完全闭塞病变介入治疗诱发血管弥漫性夹层延迟干预的安全性分析A safety assessment of delayed intervention of diffuse coronary artery dissection caused by percutaneous coronary intervention in chronic total occlusion patients
陆浩,李晨光,常书福,戴宇翔,黄东,马剑英,姚康,张峰,葛雷,钱菊英,葛均波
摘要(Abstract):
目的经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)慢性完全闭塞病变(chronic total occlusion,CTO)可能导致冠状动脉弥漫性夹层形成,观察此类患者延迟支架置入的安全性、靶血管再闭塞发生率及预测因素,以及对再次PCI治疗成功率的影响。方法回顾性分析2009年2月至2013年8月在复旦大学附属中山医院进行CTO介入治疗时导致病变血管弥漫性夹层,并采用了延迟支架置入策略的患者19例,观察住院及随访期间心脏压塞、急性心肌梗死、死亡等并发症的发生率,夹层长度及TIMI血流分级对再闭塞的影响,比较原位闭塞及非原位闭塞患者再次PCI的成功率。结果所有患者住院及随访期间未发生心脏压塞、急性心肌梗死、死亡等并发症。术后6~50周复查冠状动脉造影示,靶血管再闭塞15例(78.9%),其中原位闭塞11例,非原位闭塞4例,首次PCI术后靶血管的TIMI血流均为Ⅰ~Ⅱ级;血管再通4例,TIMI血流均为Ⅲ级。再次PCI的患者中,原位闭塞9例,正向PCI均失败,逆向PCI成功5例(55.6%);非原位闭塞4例,正向PCI3例,逆向PCI 1例,均成功;非原位闭塞再次正向PCI的成功率明显高于原位闭塞患者(P=0.003)。结论 CTO介入治疗后出现弥漫性夹层,延期支架置入术是一种可选择的治疗方案,TIMI血流Ⅲ级是血管再通的独立预测因素,若出现原位再闭塞,在有可利用的侧支循环血管的情况下,应尽早选择逆向PCI策略以提高手术的成功率。
关键词(KeyWords): 慢性完全闭塞病变;经皮冠状动脉介入治疗;血管夹层
基金项目(Foundation): 国家自然科学基金(81400318)
作者(Author): 陆浩,李晨光,常书福,戴宇翔,黄东,马剑英,姚康,张峰,葛雷,钱菊英,葛均波
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