热娜提·肉孜,吴娜琼,石惠薇,刘硕霖,董倩,高莹,郭远林,唐熠达,李建军

• 1:国家心血管病中心北京协和医学院中国医学科学院阜外医院内分泌与心血管代谢中心

摘要(Abstract)：

目的探讨因胸痛接受冠状动脉CT检查的患者血清脂蛋白a[Lp(a)]水平与冠状动脉钙化(CAC)之间的相关性。方法共入选1085例因胸痛在阜外医院接受冠状动脉CT检查的患者,根据Agatston评分算法计算冠状动脉钙化评分(CACS)。所有入选患者均检测了血脂谱和Lp(a)水平。结果根据CACS进行分组,CACS>0分组(460例)患者血清Lp(a)水平明显高于CACS=0分组(625例)患者[23.60(14.73,44.56)mg/dl比12.73(5.56,31.10)mg/dl,P<0.001],差异有统计学意义。多元线性回归分析显示,血清Lp(a)浓度与CACS呈正相关(β=0.543,P<0.001)。曲线下面积(AUC)值显示血清Lp(a)水平在预测CACS方面具有正确的区分效力(AUC=0.71,95%CI0.68～0.74,P<0.001)。Lp(a)的最佳截断值为10.51mg/dl(敏感度为86.1%,特异度为51.7%)。结论在因胸痛接受冠状动脉CT检查的患者中,血清Lp(a)水平与CAC呈显著正相关。

关键词(KeyWords)： 脂蛋白a;冠状动脉CT扫描;冠状动脉钙化

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 热娜提·肉孜,吴娜琼,石惠薇,刘硕霖,董倩,高莹,郭远林,唐熠达,李建军

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