姚康,陆浩,张春瑜,吴彦,葛雷,钱菊英,邹云增,葛均波

• 1:复旦大学附属中山医院心内科
• 2:解放军第85医院心内科

摘要(Abstract)：

目的最近研究发现新型趋化因子Fractalkine与动脉粥样硬化的炎症免疫发病有关,我们对临床各种急性冠状动脉综合征患者循环可溶性Fractalkine(sFractalkine)水平进行了观察。方法选取急性冠状动脉综合征患者56例,其中急性心肌梗死(AMI)20例,不稳定心绞痛(UP)36例,同时以25例稳定性心绞痛(SAP)作为对照,所有患者均经冠状动脉造影证实;其中不稳定心绞痛患者行血管内超声检查,对斑块性质做出判定;ELIZA法检测外周血sFractalkine及高敏C反应蛋白(hs-CRP)水平。结果 AMI组sFractalkine水平(900.9±66.6)pg/ml显著高于UP(F=4.21,P=0.0008)及SAP组(F=4.85,P=0.0006),血管内超声确定有斑块破裂的UP患者sFractalkine水平(717.8±49.1)pg/ml显著高于UP组无斑块破裂者(610.9±34.8)pg/ml(F=2.21,P=0.03),sFractalkine水平与hs-CRP呈显著正相关(r=0.329,P=0.003)。结论 sFractalkine可能与动脉粥样硬化的炎症免疫发病,尤其是在斑块破裂过程中起着重要作用。

关键词(KeyWords)： 炎症趋化因子类;急性冠状动脉综合征;动脉粥样硬化

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目资助(30900600);; 高等学校博士点新教师基金资助(20090071120027)

作者(Author): 姚康,陆浩,张春瑜,吴彦,葛雷,钱菊英,邹云增,葛均波

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