杨璐,周慧,沈文,邬涛,杨人强,程应樟

• 1:南昌大学第二附属医院心血管内科

摘要(Abstract)：

目的 探讨先天性卵圆孔未闭（PFO）相关缺血性卒中患者血清生化和全血细胞特征。方法 入选2020年1月至2021年6月于南昌大学第二附属医院诊断为先天性PFO致缺血性卒中并行介入封堵术的患者91例（PFO组）；匹配同样数目其他病因（非PFO）导致的缺血性卒中患者作为对照组。分析比较两组患者在人口学资料、脑血管传统危险因素、血清生化、全血细胞计数等方面的差异。结果 PFO组患者较对照组平均年龄更小[（55.22±15.18）岁比（64.74±12.14）岁，P<0.001]，且高血压病比例更低（27.47%比69.23%,P<0.001）。PFO组总胆固醇水平低于对照组[（4.15±0.96）mmol/L比（4.52±1.32）mmol/L,P=0.033]，而嗜酸性粒细胞在白细胞计数中占比高于对照组[（2.26±1.76）%比（1.53±1.13）%,P=0.001]。采用受试者工作特征曲线分析嗜酸性粒细胞占比对PFO相关缺血性卒中的诊断效能，结果显示曲线下面积为0.621，最佳临界值为1.42%，诊断敏感度为65.90%，特异度为56.00%。结论 先天性PFO相关缺血性卒中患者临床资料、血清生化及全血细胞计数检测均有其特征性，可为临床尽早识别、辅助缺血性卒中的病因诊断提供参考。

关键词(KeyWords)： 先天性卵圆孔未闭;缺血性卒中;血清生化;全血细胞计数

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金地区项目（81760066）

作者(Author): 杨璐,周慧,沈文,邬涛,杨人强,程应樟

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