于祥浩,于波

• 1:哈尔滨医科大学附属第二医院心血管内科

摘要(Abstract)：

<正>冠状动脉钙化(coronary artery calcifi cation,CAC)是指矿物质异常沉积在冠状动脉壁,其广泛存在于冠心病(coronary heartdisease,CHD)患者中,是CHD患者未来发生不良心血管事件的预测因子[1]。研究表明,CAC的程度与冠状动脉粥样硬化程度、未来心脏事件的发生率密切相关[2]。钙化病变的形成是一个受炎症(代谢综合征、2型糖尿病等)刺激的活跃过程。钙化病变的早期阶段,炎性因子可激活血管细胞出现成骨分化和矿化,晚期钙化与巨噬细胞含量呈负相关[3]。本文将根据近年来CAC的研究进展,从流行病学与危险因素、病理机制、诊断方法以及治疗等方面对CAC作一综述。

关键词(KeyWords)： 冠状动脉钙化;钙化机制;斑块稳定性;生物标志物

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划资助项目(2016YFC1301101);; 国家自然基金重大仪器研制项目(81827806)

作者(Author): 于祥浩,于波

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