尹文峰,李倩,任洋,吴岳

• 1:西安交通大学第一附属医院心内科西安市第一医院

摘要(Abstract)：

目的 探讨经皮冠状动脉介入治疗（PCI）老年慢性完全闭塞（CTO）病变患者的营养状态与远期预后的关系。方法 纳入2013年6月至2017年10月于西安交通大学第一附属医院346例行PCI的老年CTO病变患者，根据老年营养风险指数（GNRI）分为3组：无营养不良风险组（GNRI≥98,186例），营养不良低风险组（92≤GNRI<98,114例），营养不良中度/高度风险组（GNRI<92,46例）。主要终点事件为全因死亡，次要终点事件为心血管死亡。结果 纳入的346例患者平均年龄为72岁，中位随访33个月，Kaplan-Meier生存分析显示，营养不良中/重度风险患者在全因死亡及心血管死亡方面的预后均比其他两组差（Log-rank检验，全因死亡：P=0.004，心血管死亡：P=0.003）。多因素Cox回归分析提示全因死亡与中/重度营养不良、淋巴细胞计数及左心室射血分数相关，心血管死亡只与中/重度营养不良相关。与无营养不良风险患者相比，营养不良中/重度风险患者全因死亡及心血管死亡风险显著增加（HR 2.580,95%CI 1.139～5.842,P=0.023;HR4.709,95%CI1.321～16.787,P=0.017）。结论 入院时GNRI是老年CTO病变患者PCI术后全因死亡及心血管死亡风险的独立预测指标。

关键词(KeyWords)： 老年营养风险指数;冠状动脉慢性完全闭塞;经皮冠状动脉介入治疗;全因死亡;心血管死亡

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（81800205）

作者(Author): 尹文峰,李倩,任洋,吴岳

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