冠心病纤维蛋白原水平与冠状动脉狭窄的关系The Ralationship between Plasma Fibrinogen Levels and the Degrees of Coronary Stenosis Determined by Angiography in Cases of Coronary Heart Disease
汪芳,孙福成,杨敏,张秀萍,胡锦章
摘要(Abstract)：
选择300例行冠状动脉造影者，测定血浆纤维蛋白原（Fig）水平，观察其不同的冠脉狭窄支数及程度与Fig水平变化及其直线相关性。结果：（1）197例冠心病患者之Fig水平明显高于103例冠脉正常（NS）组（3．41±1．17vs2．74±0．65g／L，P＜0．001）。（2）在不同狭窄支数亚组中，Fig水平虽随狭窄支数增多有升高趋势，且每组的Fig水平均明显高于NS组，（P＜0．001）；但CHD各亚组之间差异无显著性。（3）冠脉狭窄程度与Fig水平间轻度相关（r＝0．2111，P＜0．001）。（4）Fig对于冠心病发病危险有一定的预测价值。即以≥3．40g／L为界值，其敏感性41．1％，特异性83．6％。提示血浆Fig浓度水平可能为冠心病的发病危险因素之一，但未发现其与冠脉狭窄程度的明显相关性。
关键词(KeyWords)： 冠状动脉造影;冠状动脉病变;纤维蛋白原
基金项目(Foundation):
作者(Author): 汪芳,孙福成,杨敏,张秀萍,胡锦章
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