王芳,边波,万征

• 1:天津医科大学总医院心血管病中心

摘要(Abstract)：

<正>再灌注心律失常(reperfusion arrhythmia,RA)是指冠状动脉(冠脉)突然解除梗阻,缺血心肌重新获得血液灌注后的一定时间内发生的心律失常,临床上可作为判断冠脉再通的一项指标,然而再灌注室颤又被认为是缺血再灌注期患者猝死的重要原因[1]。Mehta等[2]对APEX

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王芳,边波,万征

参考文献(References)：

• [1]Clements-Jewery H.Mitochondria,the calcium uniporter,and reperfusion-induced ventricular fibrillation.Br J Pharmacol,2006,149:811-813.
• [2]Mehta RH,Starr AZ,Lopes RD,et al.Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention.JAMA,2009,301:1779-1789.
• [3]Murry CE,Jennings RB,Reimer KA.Preconditioning with ischemia:a delay of lethal cell injury in ischemic myocardium.Circulation,1986,74:1124-1136.
• [4]Zhao ZQ,Corvera JS,Halkos ME,et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning.Am J Physiol Heart Circ Physiol,2003,285:579-588.
• [5]Staat P,Rioufol G,Piot C,et al.Postconditioning the human heart.Circulation,2005,112:2143-2148.
• [6]Postconditioning in ST-Elevation Myocardial Infarction(POSTEMI)[EB/OL].(2009-6-16)[2009-11-20]http://clinicaltrials.gov/ct2/show/study/NCT00922675.
• [7]Andreadou1I,Iliodromitis EK,Koufaki M,et al.Pharmacological pre-and post-conditioning agents:reperfusion-injury of the heart revisited.Mini Rev Med Chem,2008,8:952-959.
• [8]Grech ED,Ramsdale DR.Termination of reperfusion arrhythmia by coronary artery occlusion.Br Heart J,1994,72:94-95.
• [9]Galagudza M,Kurapeev D,Minasian S,et al.Ischemic postconditioning:brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm.Eur J Cardiothorac Surg,2004,25:1006-1010.
• [10]Sasaki H,Shimizu M,Ogawa K,et al.Brief ischemia-reperfusion performed after prolonged ischemia(ischemic postconditioning)can terminate reperfusion arrhythmias with noreduction of cardiac function in rats.Int Heart J,2007,48:205-213.
• [11]Kloner RA,Dow J,Bhandari A.Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion.Cardiovasc Pharmacol Ther,2006,11:55-63
• [12]Dow J,Bhandari A,Kloner RA.Ischemic postconditioning′s benefit on reperfusion ventricular arrhythmias is maintained in the senescent heart.J Cardiovasc Pharmacol Ther,2008,13:141-148.
• [13]Venardos KM,Kaye DM.Myocardial ischemia-reperfusion injury,antioxidant enzyme systems,and selenium:a review.Curr Med Chem,2007,14:1539-1549.
• [14]Ding C,Fu XH,He ZS,et al.Cardioprotective effects of simvastatin on reversing electrical remodeling induced by myocardial ischemia-reperfusion in normocholesterolemic rabbits.Chin Med J(Engl),2008,121:551-556.
• [15]Soliman D,Hamming KS,Matemisz LC,et al.Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.J Mol Cell Cardiol,2009,47:595-602.
• [16]Sun HY,Wang NP,Kerendi F,et al.Hypoxic postconditioning reduces cardiomyocyte loss by inhibiting ROS generation and intracellular Ca2+overload.Am J Physiol Heart Circ Physiol,2005,288:1900-1908.
• [17]Abdel-Rahman U,Risteski P,Tizi K,et al.Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia-reperfusion injury after cardioplegic arrest in a porcine model.J Thorac Cardiovasc Surg,2009,137:978-982.
• [18]樊泽元,杨龙,杨新春,等.缺血后处理对大鼠心室肌细胞内向整流钾电流和动作电位的影响.中国心脏起搏与心电生理杂志,2008,22:68-71.
• [19]Rodolphe PK,Laurita KR.Cellular mechanism of calcium-mediated triggered activity in the heart.Circ Res,2005,96:535-942.
• [20]Takahashi K,Takahashi T,Suzuki T,et al.Protective effects of SEA0400,a novel and selective inhibitor of the Na/Ca exchanger,on myocardial ischemia-reperfusion injuries.Eur J Pharmacol,2003,458:155-162.
• [21]Lee BH,Yi KY,Lee S,et al.Effects of KR-32570,a new sodium hydrogen exchanger inhibitor,on myocardial infarction and arrhythmias induced by ischemia and reperfusion.Eur J Pharmacol,2005,523:101-108.
• [22]Fujita M,Asanuma H,Hirata A,et al.Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.Am J Physiol Heart Circ Physiol,2007,292:2004-2008.
• [23]García-Rivas,Carvajal K,Correa F,et al.Ru360,a specific mitochondrial calcium uptake inhibitor,improves cardiac post-ischaemic functional recovery in rats in vivo.Br J Pharmacol,2006,149:829-837.
• [24]Hausenloy DJ.Signalling pathways in ischaemic postconditioning.Thromb Haemost,2009,101:626-634.
• [25]Dow J,Bhandari A,Kloner RA.The mechanism by which ischemic postconditioning reduces reperfusion arrhythmias in rats remains elusive.J Cardiovasc Pharmacol Ther,2009,14:99-103.
• [26]岳莉英,李永慧,王电烨,等.缺血后处理对大鼠缺血再灌注心律失常的影响.山西医科大学学报,2008,6:489-491.
• [27]Steinberg SF.PI3King the L-Type calcium channel activation mechanism.Circ Res,2001,89:641-644.