许锦鑫,郑洁萱,黄陶然,罗冬玲,朱瑗,张曹进,费洪文

• 1:广东省心血管病研究所广东省人民医院心内科(广东省医学科学院)南方医科大学

摘要(Abstract)：

目的 分析肺动脉高压患者右心房各时期应变与各种影响因素的相关性，以探讨右心房应变在肺动脉高压病情评估中的作用。方法 纳入2021年10月至2023年12月广东省人民医院确诊为肺动脉高压并接受超声心动图及完整右心导管检查的患者239例，测量右心房和右心室应变、右心房面积、下腔静脉内径及下腔静脉塌陷率等常规超声参数，记录对应超声图像的心率，收集其年龄、性别等一般资料及右心房平均压、肺动脉平均压、肺血管阻力等心导管检查数据，分析右心房应变及其各影响因素的关系。结果 与右心房储备期应变（RASr）相关性由高到低依次是右心室整体纵向应变（RV4CSL）、右心室游离壁纵向应变（RVFWSL）、右心房面积、下腔静脉内径、右心房平均压、年龄、心率、肺血管阻力；与右心房管道期应变（RAScd）相关性由高到低依次是RV4CSL、RVFWSL、右心房面积、下腔静脉内径、右心房平均压、年龄、肺血管阻力、心率；与右心房房缩期应变（RASct）相关性由高到低依次是右心房面积、RV4CSL、RVFWSL、右心房平均压、下腔静脉内径、年龄。总体患者中，下腔静脉塌陷率与右心房各时期应变差异有统计学意义；性别在RASr、RASct差异有统计学意义。结论 右心房应变可反映右心房功能变化，与右心房应变相关性最高的是右心室应变及右心房面积，右心房应变可反映右心室功能和右心房重构严重程度，可作为肺动脉高压病情及治疗效果的评估指标。

关键词(KeyWords)： 肺动脉高压;右心房应变;超声心动图;右心导管

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（82371963）;; 广东省自然科学基金项目（2023A1515011366）

作者(Author): 许锦鑫,郑洁萱,黄陶然,罗冬玲,朱瑗,张曹进,费洪文

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