韦苇,罗裕

• 1:同济大学附属东方医院心内科

摘要(Abstract)：

冠状动脉扩张症是冠状动脉疾病的一种,发病率较低。由于冠状动脉介入技术的发展和广泛应用,该疾病的识别和诊断率明显提高。目前该疾病的病因和发病机制尚未明确,本文就该疾病的分型、病理生理机制、临床表现及治疗方法等方面的现状和研究进展作一讨论。

关键词(KeyWords)： 冠状动脉扩张症;介入技术;冠状动脉粥样硬化

Abstract:

Keywords:

基金项目(Foundation): 上海市卫计委科学基金项目（201840112）;; 上海市浦东新区临床高峰学科基金项目（PWYgf201802）

作者(Author): 韦苇,罗裕

参考文献(References)：

• [1]Manginas A,Cokkinos DV.Coronary artery ectasias:imaging,functional assessment and clinical implications.Eur Heart J,2006,27(9):1026-1031.
• [2]Baman TS,Cole JH,Devireddy CM,et al.Risk factors and outcomes in patients with coronary artery aneurysms.Am JCardiol,2004,93(12):1549-1551.
• [3]Warisawa T,Naganuma T,Tomizawa N,et al.High prevalence of coronary artery events and non-coronary events in patients with coronary artery aneurysm in the observational group.Int J Cardiol Heart Vasc,2016,10:29-31.
• [4]Doi T,Kataoka Y,Noguchi T,et al.Coronary artery ectasia predicts future cardiac events in patients with acute myocardial infarction.Arterioscler Thromb Vasc Biol,2017,37(12):2350-2355.
• [5]Packard M,Wechsler H.Aneurysms of coronary arteries.Arch Intern Med,1929,43:1.
• [6]Maehara A,Mintz GS,Ahmed JM,et al.An intravascular ultrasound classification of angiographic coronary artery aneurysms.Am J Cardiol,2001,88(4):365-370.
• [7]Markis JE,Joff e CD,Cohn PF,et al.Clinical significance of coronary arterial ectasia.Am J Cardiol,1976,37:217-222.
• [8]Demopoulos VP,Olympios CD,Fakiolas CN,et al.The natural history of aneurysmal coronary artery disease.Heart,1997,78(2):136-141.
• [9]Swaye PS,Fisher LD,Litwin P,et al.Aneurysmal coronary artery disease.Circulation,1983,67(1):134-138.
• [10]Zeb M,McKenzie DB,Scott PA,et al.Treatment of coronary aneurysms with covered stents:a review with illustrated case.JInvasive Cardiol,2012,24(9):465-469.
• [11]Kelley MP,Carver JR.Coronary artery aneurysms.J Invasive Cardiol,2002,14(8):461-462.
• [12]Nichols L,Lagana S,Parwani A.Coronary artery aneurysm:a review and hypothesis regarding etiology.Arch Pathol Lab Med,2008,132(5):823-828.
• [13]Ozaki K,Tanaka T.Molecular genetics of coronary artery disease.J Hum Genet,2016,61:71-77.
• [14]Ahn CM,Hong BK,Kim JY,et al.Incidence and natural history of coronary artery aneurysm developing after drugeluting stent implantation.Am Heart J,2010,160(5):987-994.
• [15]Alfonso F,Pérez-Vizcayno MJ,Ruiz M,et al.Coronary aneurysms after drug-eluting stent implantation:clinical,angiographic,and intravascular ultrasound findings.J Am Coll Cardiol,2009,53(22):2053-2060.
• [16]Finn AV,Nakazawa G,Joner M,et al.Vascular responses to drug eluting stents:importance of delayed healing.Arterioscler Thromb Vasc Biol,2007,27:1500-1510.
• [17]Hofma SH,van der Giessen WJ,van Dalen BM,etal.Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation.Eur Heart J,2006,27(2):166-170.
• [18]Burgner D,Davila S,Breunis WB,et al.International Kawasaki Disease Genetics Consortium:a genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease.PLoS Genet,2009,5(1):e1000319.
• [19]Hui-Yuen J,Duong T,Yeung R.TNF-alpha is necessary for induction of coronary artery inflammation and aneurysm formation in an animal model of Kawasaki disease.J Immunol,2006,176(10):6294-6301.
• [20]Mata KM,Prudente PS,Rocha FS,et al.Combining two potential causes,of metalloproteinase secretion causes abdominal aortic aneurysms in rats:a new experimental model.Int J Exp Pathol,2011,92(1):26-39.
• [21]Mellody KT,Freeman LJ,Baldock C,et al.Marfan syndromecausing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.J Biol Chem,2006,281(42):31854-31862.
• [22]Loeys BL,Schwarze U,Holm T,et al.Aneurysm syndromes caused by mutations in the TGF-beta receptor.N Engl J Med,2006,355:788-798.
• [23]Kandarpa K,Stoll JF,Reiss C,et al.A case of neurofibromatosis associated with a coronary artery aneurysm and myocardial infarction.Cardiovasc Intervent Radiol,1988,11:143-145.
• [24]Daly MP,Rubinstein MN.A case of neurofibromatosis associated with a coronary artery aneurysm and myocardial infarction.Clin Cardiol,1992,15:616-618.
• [25]Evrengul H,Kilic DI,Zungur M,et al.Myocardial infarction in a 17-year-old patient due to neurofibromatosis-associated coronary aneurysm.Cardiol Young,2013,23(3):454-456.
• [26]Ford SR,Rao A,Kochilas L.Giant coronary artery aneurysm formation following meningococcal septicaemia.Pediatr Cardiol,2007,28(4):300-302.
• [27]Satran A,Bart BA,Henry CR,et al.Increased prevalence of coronary artery aneurysms among cocaine users circulation.Circulation,2005,111(19):2424-2429.
• [28]Tunick PA,Slater J,Kronzon I,et al.Discrete atherosclerotic coronary artery aneurysms:a study of 20 patients.J Am Coll Cardiol,1990,15:279-282.
• [29]Zoneraich S,Zoneraich O,Rhee JJ,et al.Giant coronary artery aneurysm.The cause of middiastolic murmur and bulging of the left cardiac border.JAMA,1975,231(2):179.
• [30]Eshtehardi P,Cook S,Moarof I,et al.Giant coronary artery aneurysm:imaging findings before and after treatment with a polytetrafluoroethylene-covered stent.Circ Cardiovasc Interv,2008,1(1):85-86.
• [31]Aqel RA,Zoghbi GJ,Iskandrian A.Spontaneous coronary artery dissection,aneurysms,and pseudoaneurysms:a review.Echocardiography,2004,21(2):175-182.
• [32]Forte E,Aiello M,Inglese M,et al.Coronary artery aneurysms detected by computed tomography coronary angiography.Eur Heart JCardiovasc Imaging,2017,18(11):1229-1235.
• [33]Newburger JW,Takahashi M,Gerber MA,et al.Diagnosis,treatment,and long-term management of Kawasaki disease:a statement for health professionals from the Committee on Rheumatic Fever,Endocarditis and Kawasaki Disease,Council on Cardiovascular Disease in the Young,American Heart Association.Circulation,2004,110(17):2747-2771.
• [34]Greil GF,Stuber M,Botnar RM,et al.Coronary magnetic resonance angiography in adolescents and young adults with Kawasaki disease.Circulation,2002,105:908-911.
• [35]Zhang Y,Huang QJ,Li XL,et al.Prognostic value of coronary artery stenoses,markis class,and ectasia ratio in patients with coronary artery ectasia.Cardiology,2015,131(4):251-259.
• [36]Friedman KG,Gauvreau K,Hamaoka-Okamoto A,et al.Coronary artery aneurysms in Kawasaki disease:risk factors for progressive disease and adverse cardiac events in the USpopulation.J Am Heart Assoc,2016,5:e003289.
• [37]Kim TH,Marfatia R,Lee J,et al.Giant coronary aneurysm management with Viabahn covered stent.Cardiovasc Revasc Med,2017,18:56-59.
• [38]Kuntz RE,Baim DS,Cohen DJ,et al.A trial comparing rheolytic thrombectomy with intracoronary urokinase for coronary and vein graft thrombus (the Vein Graft AngioJet Study[Ve GAS2]).Am J Cardiol,2002,89:326-330.
• [39]Cereda AF,Tiberti G,Pera IG,et al.A giant coronary artery aneurysm treated using multiple overlapping covered stents.JACCCardiovasc Interv,2017,10:e127-e128.
• [41]刘韵情，荆全民，王斌，等.经皮冠状动脉介入治疗术后瘤样扩张再置入覆膜支架2例.中国介入心脏病学杂志，2019,27(12):715-717.
• [42]Izumi K,Hisata Y,Hazam S.Surgical repair for a coronarypulmonary artery fistula with a saccular aneurysm of the coronary artery.Ann Thorac Cardiovasc Surg,2009,15:194-197.