诱导金属硫蛋白合成增强大鼠对心脏缺血再灌注损伤的抵抗The induced metallothionein increases the resistance of heart against ischemia/reperfusion injuries in rats
陈魁,张钧华,刘秀华,杨德玲,陈健,唐朝枢
摘要(Abstract)：
为探讨缺血预处理延迟保护作用的非缺血诱导方式，我们在离体大鼠心脏等容收缩灌流模型上观察到：24小时前腹腔注射ZnS4诱导心肌金属硫蛋白（MT）含量增高1．6倍；与单纯缺血再灌注组比较，诱导MT组显著减少了肌红蛋白漏出和MDA增加，减轻了心肌ATP耗竭，增强了左室做功能力，但不影响冠脉流量。因此我们认为，ZnSO4注射诱导MT合成，能代替缺血预处理，模拟出缺血预处理的延迟保护作用。
关键词(KeyWords)： 金属硫蛋白;缺血预处理;心肌
基金项目(Foundation):
作者(Author): 陈魁,张钧华,刘秀华,杨德玲,陈健,唐朝枢
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