李景业,刘少伟,李新,郭雪原,张婷,阮燕菲,刘念,杜昕,董建增,马长生

• 1:首都医科大学附属北京安贞医院心内科

摘要(Abstract)：

目的观察单纯疱疹病毒(HSV)感染与心房颤动(房颤)的相关性。方法严格筛选103例孤立性房颤患者,分为阵发性房颤组74例和持续性房颤组29例,从流行病学对照研究队列中选取72例未合并房颤的健康人群作为对照组。空腹采集静脉血,用ELISA法按试剂盒标准流程检测血清HSV1 IgG抗体、HSV2 IgG抗体水平;运用相关分析探讨患者血清高敏C反应蛋白(hs-CRP)水平与HSV1 IgG抗体、HSV2 IgG抗体滴度的关系。结果对照组、阵发性房颤组和持续性房颤组的血清HSV1 IgG抗体水平分别为(217.95±53.18)μg/ml、(304.76±57.58)μg/ml和(322.99±60.35)μg/ml,血清HSV2 IgG抗体水平分别为(307.25±64.02)μg/ml、(407.22±59.1)μg/ml和(406.63±50.67)μg/ml,hs-CRP水平分别为(2.16±0.70)mg/L、(3.90±0.59)mg/L和(3.90±0.63)mg/L;对照组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平均显著低于阵发性房颤组和持续性房颤组(均P<0.001);阵发性房颤组与持续性房颤组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平比较,差异均无统计学意义(均P>0.05)。血清HSV IgG抗体水平与hs-CRP水平呈正相关关系(rHSV1=0.532,P<0.001;r_(HSV2)=0.446,P<0.001)。结论房颤患者的血清HSV IgG抗体水平显著升高,且与血清hs-CRP水平呈正相关。

关键词(KeyWords)： 心房颤动;单纯疱疹病毒感染;高敏C反应蛋白

Abstract:

Keywords:

基金项目(Foundation): 科技部国际合作项目（2013DFB30310）;;北京市医院管理局临床医学发展专项经费资助（ZYLX201302）;;“十二五”国家科技支撑计划项目（2013BAI08B02）

作者(Author): 李景业,刘少伟,李新,郭雪原,张婷,阮燕菲,刘念,杜昕,董建增,马长生

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