冠心病介入治疗前后患者血浆P-选择素、血栓调节蛋白、纤溶酶原激活剂抑制剂-1的变化Changes of plasma P-selectin、thrombomodulin、 plasminogen activator inhibitor-1 of coronary artery disease patients before and after PTCA
应淑琴,徐耕,单江
摘要(Abstract)：
目的 旨在了解冠心病患者行经皮冠状动脉成形术 (PTCA)前后血小板、内皮功能及纤溶活性的变化。方法 以 2 6例冠状动脉造影 (CAG)阴性者为阴性对照 ,以 16例CAG阳性但不宜行PTCA者为阳性对照 ,观察 2 4例行PTCA术冠心病患者术前后P 选择素 (Ps)、血栓调节蛋白 (TM)及血浆纤溶酶原激活剂抑制物 1(PAI 1)的动态变化。结果 PTCA组Ps、TM在术后 5分钟较术前显著增加 (P均 <0 0 5 ) ,且较同时间点的阴性组有非常显著增高 (P均 <0 0 0 1) ;术后 5minCAG阳性组Ps较CAG阴性组显著增加 (P <0 0 2 ) ;在术前PTCA组和CAG阳性组PAI 1均高于CAG阴性组 (P均 <0 0 5 )。结论 PTCA术后Ps、TM的增高 ,提示血小板的激活及内皮细胞的损伤 ,急性冠脉闭塞与PTCA后再狭窄可能与此相关。
关键词(KeyWords)： 经皮冠状动脉成形术;P选择素;血栓调节蛋白;纤溶酶原激活剂抑制物1
基金项目(Foundation):
作者(Author): 应淑琴,徐耕,单江
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