冠状动脉造影正常的高血压患者心肌供血分析Myocardial blood supply of hypertensive patients with normal coronary angiography
李昭屏,孙超,杨永珍,郭静萱,陈明哲
摘要(Abstract):
目的 为了解冠状动脉造影(CAG)正常的高血压患者心肌供血情况。方法选择52例高血压病I期或Ⅱ期患者,排除心肌梗塞,心肌病,心瓣膜病等,经CAG证实冠状动脉无狭窄者,行心电图、超声心动图、负荷99TC-MIBI心肌断层显像检查;30例CAG正常无上述疾病的非高血压患者做对照。结果(1)52例高血压患者中有25例(48.1%)心肌断层显像显示有心肌缺血,对照组缺血者7例(2.3%),两组差异有显著性;(2)高血压组的室间隔厚度、左房内径明显高于对照组,舒张功能明显低于对照组;(3)高血压病程、心绞痛症状、心电图ST-T改变、左室肥厚及舒张功能在高血压缺血组和非缺血组之间差异无显著性。结论高血压患者虽然CAG正常,但核素心肌显像仍有心肌缺血存在,考虑为高血压并发微血管病变,导致冠状动脉血流储备能力(CFR)下降所致。
关键词(KeyWords): 高血压冠; 状动脉造影; 核素心肌显像; 冠状动脉血流储备
基金项目(Foundation):
作者(Author): 李昭屏,孙超,杨永珍,郭静萱,陈明哲
参考文献(References):
- 1郭静萱,毛节明,郭丽君,等.高血压病伴心肌缺血而冠状动脉造影正常病人的临床分析.中华医学杂志,1995,75:700-701。
- 2刘秀杰.核医学在心血管病应用的进展.中华心血管病杂志,1993,21:367.
- 3 Houghton JL, Prisant LM, von Dohlen TW, et al.Relations among impaired coronary flow reserve, leftventricular hypertrophy and thallium perfusion defects inhypertensive patients without obstructive coronary arterydisease. J Am Coil Cardiol, 1990, 15: 43-51.
- 4 Iriarte M, Boveda J, lopez de Argumedo M, et al.Microvascular angina pectoris in hypertensive patientswith left ventricular hypertrophy and diagnostic value ofexercise thallium-201 scintigraphy. Am J Cardiol, 1995,15; 75: 335-339.
- 5 Schelers Mott W, Transient myocardial ischaemia inhypertensive missing link with left ventricular hypertrophy. European Heart J, 1992, 13[Suppl D]: 62.
- 6 Kozakova-M, Palombo-c, Pratali-L., et al. Mechanismsof coronary flow reserve impairment in human hypertension. An integrated approach by transtroracic and transesophageal echocardiography. Hypertension, 1997, 29:551-559.
- 7 Amtony I, Nitenberg A. Coronary vascular reserve issimilarly reduced in hypertensive patient without anyother coronery risk factors and in normotensive smokersand hypercholesterolemic patients with angiographicallynormal colonay Arteries. Am J Hypetens, 1997, 10: 181-188.
- 8 Motz W, Strauer BE. Improvement of coronary flowreserve after long-term therapy with enalapril. Hypertension, 1996, 27: 1031-1038.