解文萱,李鑫玉,杨新宇,程诗琳,李欣然,王瑜,施钰根,王晔,薛梅,闫素华,胡和生

• 1:山东第一医科大学第一附属医院(山东省千佛山医院)心血管病学心律失常科山东省医药卫生心律失常重点实验室

摘要(Abstract)：

目的 分析心房颤动（AF）一站式术后Watchman 2.5封堵器中期内皮化的影响因素。方法 回顾性纳入2019年2月至2024年6月在山东第一医科大学第一附属医院接受一站式治疗的非瓣膜性AF患者75例，收集患者的临床数据。术后6个月通过冠状动脉CT血管造影（CCTA）评估封堵情况，分为封堵器完全内皮化（CDE）组和不完全内皮化（IDE）组。采用二元Logistic回归分析术后封堵器内皮化的影响因素。结果 纳入75例患者，术后随访中位时间6个月，CDE组患者38例，IDE组患者19例，18例患者存在器械残余分流（PDL）已排除。两组患者糖尿病占比比较，差异有统计学意义（P=0.030），一般资料、其他既往史、手术情况等比较，差异均无统计学意义（均P>0.05）。行二元Logistic回归分析，结果显示高血压（OR 8.347,95%CI 1.375～50.666,P=0.021）和糖尿病（OR 4.278,95%CI 1.108～16.512,P=0.035）为影响封堵器IDE的危险因素，而服用血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂（ACEI/ARB）类药物（OR 0.189,95%CI 0.043～0.833,P=0.028）和VOM无水乙醇化学消融（OR 0.110,95%CI 0.020～0.609,P=0.011）为保护因素。结论 合并高血压和糖尿病可能会增加AF一站式术后封堵器中期IDE的风险，而服用ACEI/ARB类药物和VOM无水乙醇化学消融可能会降低这种风险。

关键词(KeyWords)： 心房颤动;导管消融;左心耳封堵;内皮化;冠状动脉CT血管造影

Abstract:

Keywords:

基金项目(Foundation): 山东省自然科学基金面上项目（ZR2020MH024）;; 山东省医学会临床科研资金—齐鲁专项项目（YXH2022ZX02138）

作者(Author): 解文萱,李鑫玉,杨新宇,程诗琳,李欣然,王瑜,施钰根,王晔,薛梅,闫素华,胡和生

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