双支架术式的体外模拟研究Two-stent techniques for coronary bifurcation: insight from in vitro and virtual bench testing
高晓飞,张俊杰,葛震,肖平喜,叶飞,陈绍良
摘要(Abstract):
目的研究不同双支架术式(包括经典挤压支架术、双对吻挤压支架术和裙裤支架术)在不同分叉角度的分叉血管模型中的表现。方法基于不同分叉角度的硅树脂分叉血管模型,全程使用微聚焦相机照相,观察运用不同双支架术后的支架形态学以及分支开口间隙区的差异。结果基于"T"型分叉(远端分叉角度90°):运用经典挤压支架术,再次放置导丝从远端网眼进入分支,完成对吻扩张后,分支开口嵴侧无支架钢梁覆盖;无论是经典挤压支架术(再次放置导丝从近端网眼进入分支),还是双对吻挤压支架术(两次放置导丝都从近端网眼进入),分支开口嵴侧都留有间隙区,但双对吻挤压支架术后的间隙空间小于经典挤压支架术。基于"Y"型分叉(远端分叉角度<70°):双对吻挤压支架术和裙裤支架术后分支开口无间隙形成;裙裤支架术若两次放置导丝都从近端网眼进入分支,术后分支开口会形成新的金属嵴。结论远端分叉角度是决定双支架术后分支开口间隙形成的重要解剖学因素。对于"T"型分叉,运用挤压支架术在分支开口嵴侧都留有间隙,但双对吻挤压支架术后的间隙空间明显小于经典挤压支架术;双对吻挤压支架术两次放置导丝都应从近端网眼进入分支;裙裤支架术两次放置导丝都应从远端网眼进入分支。
关键词(KeyWords): 冠状动脉分叉;体外模拟;经典挤压支架术;双对吻挤压支架术;裙裤支架术
基金项目(Foundation): 江苏省临床医学科技专项(BL2013001)
作者(Author): 高晓飞,张俊杰,葛震,肖平喜,叶飞,陈绍良
参考文献(References):
- [1]Suwaidi JA,Yeh W,Cohen HA,et al.Immediate and one-year outcome in patients with coronary bifurcation lesions in the modern era(NHLBI dynamic registry).Am J Cardiol,2001,87:1139-1144.
- [2]Tsuchida K,Colombo A,Lefevre T,et al.The clinical outcome of percutaneous treatment of bifurcation lesions in multivessel coronary artery disease with the sirolimus-eluting stent:insights from the Arterial Revascularization Therapies Study part II(ARTS II).Eur Heart J,2007,28:433-442.
- [3]Steigen TK,Maeng M,Wiseth R,et al.Nordic PCI Study Group.Randomized study on simple versus complex stenting of coronary artery bifurcation lesions:the Nordic bifurcation study.Circulation,2006,114:1955-1961.
- [4]Ferenc M,Gick M,Kienzle RP,et al.Randomized trial on routine vs.provisional T-stenting in the treatment of de novo coronary bifurcation lesions.Eur Heart J,2008,29:2859-2867.
- [5]Colombo A,Bramucci E,Sacca S,et al.Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations:the CACTUS(Coronary Bifurcations:Application of the Crushing Technique Using Sirolimus-Eluting Stents)Study.Circulation,2009,119:71-78.
- [6]Erglis A,Kumsars I,Niemela M,et al.Randomized comparison of coronary bifurcation stenting with the crush versus the culotte technique using sirolimus eluting stents:The Nordic Stent Technique Study.Circ Cardiovasc Intervent,2009,2:27-34.
- [7]Murasato Y,Horiuchi M,Otsuji Y.Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography.Catheter Cardiovasc Interv,2007,70:211-220.
- [8]Murasato Y,Hikichi Y,Horiuchi M.Stent deformation and gap formation after complex stenting of left main coronary artery bifurcation using mircro focus computed tomography.J Interv Cardiol,2009,22,135-144.
- [9]Ormiston JA,Webster MWI,Webber B,et al.The crush technique for coronary artery bifurcation stenting:insights from micro-computed tomographic imaging of bench deployment.JACC Cardiovasc Interv,2008,1:351-357.
- [10]Hikichi Y,Inoue T,Node K.Benefits and limitations of Cypher stent-based bifurcation approachs:in vitro evaluation using micro-focus CT scan.J Interv Cardiol,2009,22:128-134.
- [11]Chen SL,Ye F,Zhang JJ,et al.DK crush technique:modified treatment of bifurcation lesions in coronary artery.Chin Med J,2005,118:1746-1750.
- [12]Hoye A,Iakovou I,Ge L,et al.Long-term outcomes after stenting of bifurcation lesions with the crush technique:predictors of an adverse outcomes.J Am Coll Cariol,2006,47:1949-1958.
- [13]Chen SL,Teguh Santoso,Zhang JJ,et al.Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions.Chin Med J,2012,125:2083-2088.
- [14]Zhang JJ,Chen SL,Ye F,et al.Double kissing crush technique for treatment of true coronary bifurcation lesions:two-year clinical outcomes from DKCRUSH-I study.Chin Med J,2009,122:736-740.
- [15]Zhang JJ,Chen SL,Ye F,et al.Mechanisms and clinical significance of quality of final kissing balloon inflation in patients with true bifurcation lesions treatment by crush stenting technique.Chin Med J,2009,122:2086-2091.
- [16]Hildick-Smith D,Lassen JF,Albiero R,et al.Consensus from the 5th European Bifurcation Club meeting.Euro Intervention,2010,6:34-38.