氯吡格雷药物基因组多态性与个体化治疗研究进展
宋博凡,高方明
摘要(Abstract):
<正>氯吡格雷联合阿司匹林仍然是国内冠状动脉粥样硬化性心脏病(冠心病)患者抗血小板治疗的首选药物,而氯吡格雷更是目前抗血小板治疗的基石。经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后接受氯吡格雷常规口服剂量治疗的临床疗效显著,但是存在明显的个体差异,仍有部分患者再发心血管缺血事件,如支架内血栓、急性心肌梗死、猝死等。氯吡格雷抵抗为氯吡格雷低反应可能
关键词(KeyWords): 氯吡格雷;基因多态性;抗血小板治疗;个体化治疗
基金项目(Foundation):
作者(Author): 宋博凡,高方明
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