基于无创冠状动脉CT造影的血流储备分数在冠心病诊治中的研究进展
张旻,龚艳君
摘要(Abstract):
<正>冠心病目前是人们关注度最高的心血管疾病。临床上影像学诊断冠心病最常用的方法有两种:无创冠状动脉CT造影(coronary computed tomography angiography,CCTA)和有创冠状动脉造影(invasive coronary angiography,ICA)。然而,这两种方法仅可以从解剖学角度评价冠状动脉是否狭窄及判断狭窄的程度,并不能从血流灌注情况评价冠状动脉病变
关键词(KeyWords): 冠状动脉CT造影;血流储备分数;冠心病
基金项目(Foundation):
作者(Author): 张旻,龚艳君
参考文献(References):
- [1]Tonino PA,Fearon WF,De Bruyne B,et al.Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation.J Am Coll Cardiol,2010,55(25):2816-2821.
- [2]Koo BK.The present and future of fractional flow reserve.Circ J,2014,78(5):1048-1054.
- [3]Shaw LJ,Berman DS,Maron DJ,et al.Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden:results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation(COURAGE)trial nuclear substudy.Circulation,2008,117(10):1283-1291.
- [4]Tonino PA,De Bruyne B,Pijls NH,et al.Fractional flow reserve versus angiography for guiding percutaneous coronary intervention.N Engl J Med,2009,360(3):213-224.
- [5]李琪,刘健,卢明瑜,等.血流储备分数与冠状动脉造影指导不稳定型心绞痛患者临界病变介入治疗效果的比较.中国介入心脏病学杂志,2014,22(1):7-11.
- [6]Pijls NH,De Bruyne B,Peels K,et al.Measurement of fractional flow reserve to assess the functional severity of coronaryartery stenoses.N Engl J Med,1996,334(26):1703-1708.
- [7]Taylor CA,Fonte TA,Min JK.Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve:scientific basis.J Am Coll Cardiol,2013,61(22):2233-2241.
- [8]陆怡菡,曾蒙苏.FFRCT:无创冠脉血流储备分数检测方式.中国医学计算机成像杂志,2014,20(2):200-204.
- [9]Koo BK,Erglis A,Doh JH,et al.Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms.Results from the prospective multicenter DISCOVER-FLOW(Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve)study.J Am Coll Cardiol,2011,58(19):1989-1997.
- [10]Min JK,Leipsic J,Pencina MJ,et al.Diagnostic accuracy of fractional flow reserve from anatomic CT angiography.JAMA,2012,308(12):1237-1245.
- [11]Nakazato R,Park HB,Berman DS,et al.Noninvasive fractional flow reserve derived from computed tomography angiography for coronary lesions of intermediate stenosis severity:results from the De FACTO study.Circ Cardiovasc Imaging,2013,6(6):881-889.
- [12]Gaur S,Achenbach S,Leipsic J,et al.Rationale and design of the Heart Flow NXT(Heart Flow analysis of coronary blood flow using CT angiography:Ne Xt s Teps)study.J Cardiovasc Comput Tomogr,2013,7(5):279-288.
- [13]Norgaard BL,Leipsic J,Gaur S,et al.Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease:the NXT trial(Analysis of Coronary Blood Flow Using CT Angiography:Next Steps).J Am Coll Cardiol,2014,63(12):1145-1155.
- [14]Douglas PS,Pontone G,Hlatky MA,et al.Clinical outcomes of fractional flow reserve by computed tomographic angiographyguided diagnostic strategies vs.usual care in patients with suspected coronary artery disease:the prospective longitudinal trial of FFR(CT):outcome and resource impacts study.Eur Heart J,2015,36(47):3359-3367.
- [15]Hlatky MA,Saxena A,Koo BK,et al.Projected costs and consequences of computed tomography-determined fractional flow reserve.Clin Cardiol,2013,36(12):743-748.
- [16]Hlatky MA,De Bruyne B,Pontone G,et al.Quality-of-Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography:PLATFORM.J Am Coll Cardiol,2015,66(21):2315-2323.
- [17]Douglas PS,De Bruyne B,Pontone G,et al.1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease:The PLATFORM Study.J Am Coll Cardiol,2016,68(5):435-445.