郑婕舒,张元春,刘祖恒,熊赖焱,戴磊,罗常有,王善花,尹庆

• 1:中山大学附属东华医院心内科

摘要(Abstract)：

目的通过分析急性冠状动脉综合征(ACS)患者血清超敏C反应蛋白及抵抗素浓度与罪犯病变虚拟组织学-血管内超声(VH-IVUS)特点相关性,研究血清超敏C反应蛋白及抵抗素影响斑块易损性的机制。方法选取ACS患者60例,运用酶联免疫分析法(ELISA法)检测血清抵抗素浓度及血清超敏C反应蛋白浓度。结合心电图检查ST-T发生改变的导联,超声心动图出现室壁运动异常的节段以及冠状动脉造影发现复杂病变的部位确定罪犯病变。从而研究ACS患者血清抵抗素及超敏C反应蛋白浓度与ACS罪犯病变VH-IVUS特点的相关性。结果超敏C反应蛋白浓度的中位数为3.66 mg/L,四分位数间距为2.21 mg/L。抵抗素浓度的中位数为3.53 mg/L,四分位数间距为6.28 mg/L。ACS患者血清抵抗素浓度与罪犯病变坏死核心体积绝对值呈正相关(r=0.427,P=0.01);ACS患者血清超敏C反应蛋白浓度与罪犯病变坏死核心体积绝对值也呈正相关(r=0.322,P=0.01)。结论 ACS患者血清超敏C反应蛋白及抵抗素浓度的增加都伴随着罪犯病变脂质池的扩大。血清抵抗素浓度在评价斑块易损性方面可能较血清超敏C反应蛋白浓度更加敏感。

关键词(KeyWords)： 急性冠状动脉综合征;罪犯病变;抵抗素;超敏C反应蛋白;虚拟组织学-血管内超声

Abstract:

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基金项目(Foundation): 2012年广东省科技计划项目(2012B031800272)

作者(Author): 郑婕舒,张元春,刘祖恒,熊赖焱,戴磊,罗常有,王善花,尹庆

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