孙国举,谢秀梅,陈晓彬,巫相宏,余国龙,蒲晓群

• 1:中南大学湘雅医院心内科
• 2:中南大学湘雅医院心内科
• 3:中南大学湘雅医院心内科
• 4:中南大学湘雅医院心内科

摘要(Abstract)：

目的建立再狭窄内皮细胞模型并探讨非诺贝特对经皮冠状动脉治疗后再狭窄的防治作用。方法体外培养人脐静脉内皮细胞(HUVECs),分为:(1)正常对照组,(2)溶血卵磷脂(LPC)组,(3)低浓度非诺贝特组(10μmol/L),(4)中浓度非诺贝特组(50μmol/L),(5)高浓度非诺贝特组(100μmol/L)。分别观测内皮细胞增殖、凋亡及上清液一氧化氮(NO)浓度的的变化。结果与正常对照组比较,LPC抑制内皮细胞增殖,促进细胞凋亡,降低NO浓度。非诺贝特可干预LPC对内皮细胞的作用,使内皮细胞增殖增强,细胞凋亡减少,NO浓度升高。结论非诺贝特可改善LPC对HUVECs的影响,使内皮细胞增殖增强,凋亡减少,升高NO浓度,从而起到防治PCI后再狭窄的作用。

关键词(KeyWords)： 非诺贝特;内皮;增殖;凋亡

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 孙国举,谢秀梅,陈晓彬,巫相宏,余国龙,蒲晓群

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