沈迎,丁风华,张瑞岩,沈卫峰

• 1:上海交通大学医学院附属瑞金医院心脏科

摘要(Abstract)：

<正>近年来，随着老龄化社会的形成和人民生活水平的提高，我国的冠心病发生率明显增高。同时，冠心病治疗手段（包括药物、介入和外科手术）也有了迅猛发展，使冠心病（特别是心肌梗死）患者的急性期死亡率显著降低[1-2]。然而，许多患者在疾病进展过程中，发生严重的左心室收缩功能减退（left ventricular systolic dysfunction,LVSD）或心力衰竭[3]。大量研究表明，左心室功能减退程度和冠状动脉病变严重性是决定冠心病患者临床预后的重要因素。因此，针对这一日渐增多的冠心病合并LVSD人群，如何采用有效的治疗策略，改善左心室功能

关键词(KeyWords)： 左心室收缩功能减退;血运重建

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 沈迎,丁风华,张瑞岩,沈卫峰

参考文献(References)：

• [1]龚艳君，霍勇.开启心血管介入治疗大国到强国的征程[J].中国介入心脏病学杂志，2019,27(1):1-2.
• [2]霍勇.中国胸痛中心建设理论与医学模式[J].中国介入心脏病学杂志，2021,29(1):1-3.
• [3] Parikh PB, Bhatt DL, Bhasin V, et al. Impact of percutaneous coronary intervention on outcomes in patients with heart failure.JACC State-of-the-Art Review[J]. J Am Coll Cardiol, 2021,77(19):2432-2447.
• [4] Yanagawa B, Lee J, Puskas JD, et al. Revascularization in left ventricular dysfunction:an update[J]. Curr Opin Cardiol,2019,34(5):536-542.
• [5] Velazquez EJ, Lee KL, Dejia MA, et al. Coronary artery bypass surgery in patients with left ventricular dysfunction[J]. N Engl J Med,2011,364(17):1607-1616.
• [6] Petrie MC, Jhund PS, She L, et al., STICH Trial Investigators. Tenyear outcomes after coronary artery bypass grafting according to age in patients with heart failure and left ventricular systolic dysfunction:an analysis of the extended follow-up of the STICH Trial(Surgical Treatment for Ischemic Heart Failure)[J].Circulation,2016,134(18):1314-1324.
• [7] Perera D,Clayton T,O’Kane PD,et al. Percutaneous revascularization for Ischemic left ventricular dysfunction[J]. N Engl J Med,2022.[Online ahead of print].
• [8] Wolff G, Dimitroulis D, Andreotti F, et al. Survival benefits of invasive versus conservative strategies in heart failure in patients with reduced ejection fraction and coronary ar tery disease:a metaanalysis[J]. Circ Heart Fail,2017,10(1):e003255
• [9] Iribarne A, Di Scipio AW, Leavitt BJ, et al. Comparative eff ectiveness of coronary artery bypass grafting versus percutaneous coronary intervention in a real-world surgical treatment for ischemic heart failure trial population[J]. J Thorac Cardiovasc Surg, 2018, 156(4):1410.
• [10] Sun LY, Gaudino M, Chen RJ, et al. Long-term outcomes in patients with severely reduced left ventricular ejection fraction undergoing percutaneous coronary intervention vs. coronary artery bypass grafting[J]. JAMA Cardiol,2020,5(6):631-641.
• [11] Bangalore S, Guo Y, Samadashvill Z, et al. Revascularization in patients with multivessel coronary artery disease and severe left ventricular systolic dysfunction:everolimus-eluting stents versus coronary artery bypass fraft surgery[J]. Circulation, 2016, 133(22):2132-2140.
• [12] Park S, Ahn JM, Kim TO, et al. IRIS-MAIN Registry Investigators.Revascularization in patients with left main coronary artery disease and left ventricular dysfunction[J]. J Am Coll Cardiol, 2020, 76(12):1395-1406.
• [13] Thuijs D, Miojevic M, Stone GW, et al. Impact of left ventricular ejection fraction on clinical outcomes after left main coronary artery revascularization:results from the randomized EXCEL trial[J].Eur J Heart Fail,2020,22(5):871-879.
• [14] Kunadian V, Pugh A, Zaman AG, et al. Percutaneous coronary intervention among patients with lef t ventricular systolic dysfunction:a review and meta-analysis of 19 clinical studies[J].Coron Artery Dis,2012,23(7):469-479.
• [15] Maron DJ, Hochman JS, Reynolds HR, et al. Initial invasive or conservative strategy for stable coronary disease[J]. N Engl J Med,2020,382(15):1395-1407.
• [16]沈迎，丁风华，张瑞岩，等.冠状动脉狭窄功能学评估临床进展[J].中国介入心脏病学杂志，2021,29(3):121-123.
• [17]沈卫峰，丁风华，张瑞岩.冠状动脉腔内影像学指导左主干病变介入治疗[J].中国介入心脏病学杂志，2021,29(9):481-483.
• [18] Brophy TJ, Warsavage TJ, Hebbe AL, et al. Percutaneous coronary intervention in patients with stable coronary artery disease and left ventricular systolic dysfunction:insights from the VA CART program[J]. Am Heart J,2021,235:149-157
• [19]李琪，王伟民，刘健，等.冠状动脉介入治疗对不稳定型心绞痛患者心功能和中长期预后的影响[J].中国介入心脏病学杂志，2022,30(9):672-676.
• [20] Galassi AR, Boukhris M, Toma A, et al. Percutaneous coronary intervention of chronic total occlusions in patients with low left ventricular ejection fraction[J]. J Am Coll Cardiol Intv, 2017, 10(21):2158-2170.
• [21] Russo JJ, Prasad M, Doshi D, et al. Improvement in left ventricular function following higher-risk percutaneous coronary intervention in patients with ischemic cardiomyopathy[J]. Catheter Cardiovasc Interv,2020,96(4):764-770.
• [22] Shen Y, Aihemaiti M, Shu XY, et al. Circulating chromogranin B is associated with left ventricular functional recovery after successful recanalization of chronic total occlusion[J]. Front Cardiovasc Med,2021,8:756594.
• [23]沈迎，全进伟，杨晨蝶，等.冠状动脉侧支循环对冠状动脉慢性闭塞病变伴心力衰竭患者介入治疗后左心功能的影响[J].中国介入心脏病学杂志，2022,30(9):653-659.
• [24] Adachi Y, Kiyosue A, Ando J, et al. Factors associated with left ventri.cular reverse remodeling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction[J].Sci Rep,2021,11(1):239.
• [25] Pirnat M, Stillman AE, Rienmueller R, et al. Can the degree of coronary collateralization be used in clinical routine as a valid angiographic parameter of viability[J]? Int J Cardiovasc Imaging,2021,37(2):379-388.
• [26] Schumacher SP, Everaars H, Stuijfzand WJ, et al. Coronary collaterals and myocardial viability in patients with chronic total occlusions[J]. EuroIntervention,2020,16(6):e453-e461.
• [27] Hara M, Sakata Y, Nakatani D, et al.OACIS Investigators. Impact of coronary collaterals on in-hospital and 5-year mortality after STelevation myocardial infarction in the contemporary percutaneous coronary intervention era:a prospective observational study[J].BMJ Open,2016,6(7):e011105.
• [28] Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization[J]. Eur Heart J,2019,40(2):87-165.
• [29] Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization:a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines[J]. Circulation, 2022,145(3):e18-e114.
• [30]游洁芸，耿立，沈运丽，等.脉搏指数连续心排血量监测改善急性心肌梗死合并心原性休克患者临床预后研究[J].中国介入心脏病学杂志，2022, 30(9):665-671.