王耿,李根,刘惠亮,柳景华,贾永平,马根山,周旭晨,王守力,浦奎,韩雅玲

• 1:沈阳军区总医院心内科
• 2:武警总医院心内科
• 3:安贞医院心内科
• 4:山西医科大学第一附属医院心内科

摘要(Abstract)：

目的通过对CREDITⅡ、Ⅲ研究中的糖尿病亚组资料进行分析,探讨第二代聚合物涂层可降解钴铬合金西罗莫司(雷帕霉素)洗脱支架(EXCEL2)在糖尿病患者中的有效性和安全性。方法入选了CREDITⅡ、Ⅲ研究中置入EXCEL2支架的所有患者。主要终点为24个月的靶病变失败,以心源性死亡、靶血管心肌梗死和临床驱动的靶病变血运重建为复合终点。次要终点为患者相关复合终点,包括全因死亡、心肌梗死和血运重建。结果入选828例患者24个月随访率99.5%,糖尿病组与非糖尿病组比较,主要终点事件发生率(P>0.05)及次要终点发生率[全因死亡(2.5%比1.4%,P=0.290)、心肌梗死(7.5%比5.0%,P=0.215)、任何血运重建(5.0%比3.9%,P=0.533)以及支架内血栓形成(0.6%比0.5%,P=0.577)],差异均无统计学意义。结论 EXCEL2支架可降低糖尿病患者术后支架内再狭窄、靶病变血运重建率及支架内血栓形成风险,且不劣于非糖尿病患者。

关键词(KeyWords)： 药物洗脱支架;糖尿病;靶血管再次血运重建

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王耿,李根,刘惠亮,柳景华,贾永平,马根山,周旭晨,王守力,浦奎,韩雅玲

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