张瑞涛,田振宇,何立芸,米琳,郭丽君,徐昕晔

• 1:北京大学第三医院心内科血管医学研究所血管稳态与重构全国重点实验室国家卫生健康委心血管分子生物学与调节肽重点实验室心血管受体研究北京市重点实验室

摘要(Abstract)：

目的 以血流储备分数（FFR）为金标准，比较对比剂诱导的跨病变压力比值（cFFR）、静息全周期比值（RFR）与定量血流分数（QFR）评估冠状动脉临界病变的准确性及临床应用价值。方法 回顾性纳入2020年9月至2022年1月于北京大学第三医院进行冠状动脉造影（CAG）并接受c FFR、RFR、QFR和FFR检测的143例患者（143支病变），收集患者的临床和CAG病变解剖学资料以及靶血管c FFR、RFR、QFR和FFR检测值。分析c FFR、RFR、QFR和FFR检测的相关性和诊断一致性。结果 入选的143例患者平均年龄66(58,71)岁，90例（62.9%）为男性，60例（42.0%）患者诊断为不稳定型心绞痛，其中，115处（80.4%）靶病变位于左前降支。相关性分析显示，c FFR、RFR、QFR均与FFR显著相关（r=0.956;r=0.861;r=0.751，均P<0.001）,Bland-Altman分析表明RFR、QFR、c FFR均与FFR具有较高一致性。受试者工作特征（ROC）曲线分析显示，cFFR对应FFR≤0.80的曲线下面积（AUC）为0.96(95%CI 0.94～0.99);RFR对应FFR≤0.80的AUC为0.92(95%CI 0.87～0.96);QFR对应FFR≤0.80的AUC为0.89(95%CI 0.83～0.95)，三类检查的诊断一致性之间差异无统计学意义。结论 c FFR、RFR、QFR与FFR有较高的一致性，三者与FFR诊断一致性基本一致。

关键词(KeyWords)： 对比剂诱导的跨病变压力比值;静息全周期比值;定量血流分数;血流储备分数;冠状动脉功能学检测

Abstract:

Keywords:

基金项目(Foundation): 北京大学第三医院2022年度院创新转化基金项目（BYSYZHKC2022106）

作者(Author): 张瑞涛,田振宇,何立芸,米琳,郭丽君,徐昕晔

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