张剑,韩雅玲,荆全民,王效增,李毅,张磊,霍勇,张岩

• 1:沈阳军区总医院心内科
• 2:北京大学第一医院

摘要(Abstract)：

目的经多层冠状动脉CT检查测定的冠状动脉钙化积分对冠心病的诊断具有一定预测价值。而冠心病的危险因素与冠心病的发生、发展、结局和预后密切相关。我们旨在探讨冠状动脉钙化积分与冠心病诸多危险因素之间是否具有相关性。方法入选2001年1月至2007年3月在全国20家医院住院疑诊冠心病患者,采用16排或64排螺旋CT进行冠状动脉增强扫描,并运用自动分析软件进行冠脉钙化积分分析,共入选患者311例,根据冠状动脉钙化积分值分为低分值组(0～12)、中分值组(13～445)和高分值组(446以上),比较冠状动脉钙化积分与冠心病危险因素之间的关系。结果不同冠状动脉钙化积分分组之间,平均年龄、冠心病家族史比例、高密度脂蛋白数值和糖尿病比例等方面存在差异,P<0.05。多元Logistic回归分析显示,疑诊冠心病患者年龄(OR=1.061,95%CI1.004～1.121,P=0.036)和低HDL-C水平(OR=0.321,95%CI0.113～0.909,P=0.032)是冠状动脉钙化积分的显著相关危险因素。结论年龄、冠心病家族史、低HDL和糖尿病等冠心病危险因素与冠状动脉钙化密切相关,合并多种冠心病危险因素的患者,尤其是老年和低HDL-C患者,行多层冠状动脉CT检查及冠状动脉钙化积分测定,对冠心病的早期诊断具有一定帮助。

关键词(KeyWords)： 冠状动脉疾病;体层摄影术,螺旋计算机;危险因素

Abstract:

Keywords:

基金项目(Foundation): 十一五国家科技支撑计划(2006BAI01A02)

作者(Author): 张剑,韩雅玲,荆全民,王效增,李毅,张磊,霍勇,张岩

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