银杏叶提取物抗增生作用的实验研究The experimental study on the protective effect of GBE in intimal proliferation induced by endotkelial injury
谢苗荣,沈潞华
摘要(Abstract)：
用大鼠胸主动脉内皮损伤的模型研究了血小板活化因子（PAF）在血管内皮损伤后内膜增生中的作用及PAF受体桔抗刘银杏叶提取物（GBE）的抗增生作用。50只雄性Wistar大鼠分成5组：假手术组（S），对照组（C），大剂量GBE组（GH），小剂量GBE组（GL）及GBE中途治疗组（GM）。所有动物在术前及术后6、48小时1及2周时采血测PAF、GMP－140和D－Dimer。2周末胸主动脉切片测新生内膜面积及内膜／中膜面积比。结果表明，动脉内皮损伤后血浆PAF、GMP－140和D－Dimer均显著升高。GBE术前开始用药者（GH，GL组）可使GMP－140及D－Dimer明显下降，且作用与剂量大小有关。术后开始用药（GM）对PAF、GMP－140及D－Dimer均无影响。2周时病理切片显示，动脉内皮损伤可引起内膜的显著增生，而GBE可减轻内膜增生的程度，作用亦与剂量大小有关。术后1周开始用药者虽不能抑制PAF、GMP－140及D－Dimer水平的升高，但亦能减轻内膜增生。
关键词(KeyWords)： 血小板活化因子（PAF）;银杏叶提取物（GBE）;增生
基金项目(Foundation):
作者(Author): 谢苗荣,沈潞华
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