C型钠尿肽在糖尿病兔股动脉狭窄中的作用C type natriuretic peptide in femoral atery stenosis in diabetic rabbit models
白玲强,刘朝中,田建伟,王刚,庞博
摘要(Abstract)：
目的观察糖尿病兔股动脉球囊损伤后血浆C反应蛋白(CRP)、C型钠尿肽(CNP)浓度变化和外源性CNP干预后血管狭窄程度的影响,以探讨CNP在糖尿病下肢血管介入后再狭窄中的作用。方法糖尿病兔建模后分为对照组、球囊损伤组、CNP干预组,每组8只。用酶联免疫吸附法测定血浆CRP、CNP的浓度。术后4周处死兔,取股动脉行HE染色,分析血管内膜、中膜的变化及管腔狭窄程度。结果球囊损伤组血浆CNP浓度术后1天达峰、7天、14天较对照组增高(1天,16.38±3.76μg/L比4.20±0.84μg/L,P<0.01;7天,10.81±3.37μg/L比4.58±2.18μg/L,P<0.01;14天,6.94±2.73μg/L比4.33±0.98μg/L,P<0.05),差异均有统计学意义。CNP干预组与球囊损伤组术后不同时间的CRP浓度分别为:1天,8.43±0.61μg/mL比13.81±4.30μg/mL,P<0.01;7天,6.79±4.39μg/mL比9.38±2.99μg/mL,P<0.01;14天,5.79±0.64μg/mL比6.88±0.92μg/mL,P<0.01。干预组血管中膜面积、内膜面积与球囊损伤组相比分别为:0.14±0.05 mm2比0.28±0.18mm2,P<0.01;0.07±0.03 mm2比0.14±0.09 mm2,P<0.01。结论CNP参与糖尿病股动脉血管球囊损伤后的修复过程,对糖尿病下肢血管介入后再狭窄有一定抑制作用。
关键词(KeyWords)： 利钠肽,C型;糖尿病;股动脉;兔
基金项目(Foundation):
作者(Author): 白玲强,刘朝中,田建伟,王刚,庞博
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