何国祥,蒋清安,苗莉,刘建平,景涛

• 1:第三军医大学附属西南医院心内科重庆市介入心脏病学研究所

摘要(Abstract)：

目的探讨兔实验性心肌梗死(MI)时在心肌缺血和非缺血区域施加一定强度稳恒直流电场对梗死心肌的修复效应。方法家兔40只均予冠状动脉前降支结扎,分为心肌梗死(MI)组、平面电场2.0V组与平面电场3.0V组、透壁电场2.0V组与透壁电场3.0V组。分别给予相应的直流电场干预。4周后去甲肾上腺素激发实验分析心功能;Masson染色评估心肌梗死面积和心肌纤维化程度。结果平面电场2.0V、透壁电场2.0V和透壁电场3.0V治疗可改善MI后的收缩和舒张功能,也明显缩小了MI后瘢痕面积,同时降低梗死区边缘带纤维化程度,尤以透壁电场3.0V治疗时显著,而平面电场3.0V则无显著作用。结论适宜的低压稳恒直流电场可缩小兔实验性MI面积,降低心肌纤维化程度,改善左心室功能,对梗死心肌起到保护作用。

关键词(KeyWords)： 低压稳恒直流电场;心肌梗死;动物,实验;兔

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(30470452)

作者(Author): 何国祥,蒋清安,苗莉,刘建平,景涛

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