郑博,陈明,彭红玉,王新刚,王皓正,霍勇

• 1:北京大学第一医院心血管内科

摘要(Abstract)：

目的评价新型L605钴铬合金平台可降解聚乳酸共聚物载体西罗莫司药物洗脱支架(bioabsorbable polymeric sirolimus-eluting stent,BPSES)在小型猪冠状动脉抑制新生内膜增殖的有效性和安全性。方法金属裸支架(bare mental stent,BMS)18枚、单纯可降解聚乳酸共聚物涂层支架(bioabsorbable polymer-only stent,BPOS)18枚以及BPSES 18枚被分别随机置入18头小型猪的前降支(18枚)、回旋支(18枚)以及右冠状动脉(18枚)。置入28天和90天,复查冠状动脉造影评价管腔丢失。置入7天、28天以及90天处死部分动物行塑料包埋硬组织切片染色组织形态学分析。结果置入28天及90天,BPSES与BMS相比,显著降低管腔丢失(28天0.54±0.45 mm比1.11±0.45mm,P=0.048;90天0.42±0.34 mm比0.96±0.41 mm,P=0.024)。在损伤积分相似的情况下,置入28天时BPSES较BMS新生内膜面积明显减少(0.90±0.40 mm2比1.88±0.71 mm2,P=0.015),而在90天时亦可见此趋势。7天、28天和90天BPSES和BPOS炎症反应及内皮化程度与BMS相似。结论BPSES在置入小型猪冠状动脉28天后,可以安全有效地抑制新生内膜增殖,90天时亦可见此趋势。

关键词(KeyWords)： 支架;西罗莫司;药物载体;冠状动脉再狭窄;猪,雏型;可降解聚乳酸共聚物

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 郑博,陈明,彭红玉,王新刚,王皓正,霍勇

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