彭欣,刘健

• 1:北京大学人民医院心血管内科急性心肌梗死早期预警和干预北京市重点实验室

摘要(Abstract)：

阻塞性睡眠呼吸暂停（OSA）是一种临床常见睡眠相关疾病，此疾病多由于肥胖所致舌根部及扁桃体增大压迫、先天性颌面畸形、喉部肌肉松弛等因素导致气道狭窄，阻力增加。主要临床表现为睡眠过程中反复出现上呼吸道的完全或不完全阻塞，表现为呼吸暂停和低通气，进一步导致间歇性低氧血症、高碳酸血症及睡眠结构紊乱。急性冠状动脉综合征（ACS）是冠状动脉粥样硬化性心脏病中常见的一个类型，其以发病率高、死亡率高著称。近年来，ISAACC、SAVE、OSA-ACS等从多方面对OSA和ACS进行了研究，本文将从疾病流行病学、病理生理学、临床诊断/评估及医学干预等多个方面对OSA合并ACS进行综述，探索两者间的相关性。

关键词(KeyWords)： 急性冠状动脉综合征;阻塞性睡眠呼吸暂停;发病机制;诊疗

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目（11832003）;国家自然科学基金面上项目（81970294）;; 北京自然科学基金面上项目（7212119）;; 北京大学人民医院研究与发展基金（科研）（RDH2021-01）

作者(Author): 彭欣,刘健

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