刘威,康林,曹贵方

• 1:国家食品药品监督管理局医疗器械技术审评中心
• 2:清华大学第一附属医院
• 3:首都医科大学附属北京安贞医院

摘要(Abstract)：

目的探讨抗衰老因子klotho与急性心肌梗死发生的关系。方法对92例急性心肌梗死患者(病例组)与114例对照者(对照组)进行危险因素调查,采用ELISA法测定血清klotho表达水平。结果病例组吸烟、高血压、糖尿病比例高于对照组(P均<0.05),而血清klotho水平则低于对照组(中位数32 pg/ml比43 pg/ml,P<0.001)。以klotho血清值的中位数37 pg/ml作为分界值,高血清klotho的OR值为0.345(95%CI:0.171～0.693)。结论血清klotho表达水平可能与急性心肌梗死的发生相关,血清klotho蛋白高表达可能有降低急性心肌梗死发生的作用。

关键词(KeyWords)： 心肌梗死;动脉粥样硬化;衰老;危险因素

Abstract:

Keywords:

基金项目(Foundation): 首都医学科研基金(2007-3119);; 清华大学裕元医学基金(20240000560)

作者(Author): 刘威,康林,曹贵方

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