奥德格尔勒·图木尔,韩江莉,毛节明

• 1: 北京大学第三医院心内科
• 2:北京大学第三医院心内科
• 3:北京大学第三医院心内科

摘要(Abstract)：

目的评价绝经后女性患者血清抵抗素(Resistin)水平与冠心病病变严重程度的相关性,并探讨抵抗素水平与心血管病危险因素的关系。方法117例绝经后妇女,均检测血清抵抗素、胰岛素,并检测空腹血糖(BG)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fib)水平及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及脂蛋白(a)[Lp(a)]等血脂水平指标。根据冠状动脉病变严重程度分为4组:第1组为冠状动脉无病变者,第2组为冠状动脉轻度病变者,第3组为冠状动脉中度病变者,第4组为冠状动脉重度病变者。有中、重度病变的患者诊断为冠心病。结果冠心病患者血清抵抗素水平显著高于无冠心病的患者[4(1~10)μg/L比2(0~4)μg/L,中位数(四分位数间距)]。多元logistic回归分析显示,血清抵抗素为冠心病独立危险因素(OR1.131;95%CI1.012~1.263)。抵抗素水平与冠状动脉病变程度呈正相关(r=0.231)。控制其他心血管病危险因素后,抵抗素仍然与冠状动脉病变程度呈正相关(r=0.246)。抵抗素水平与患者年龄及hs-CRP呈正相关(r值分别为0.204和0.166,P值分别为0.001及0.009)。结论绝经后妇女血清抵抗素水平可能为冠心病的独立危险因素,并且与冠状动脉病变的严重程度可能存在一定的正相关。由于抵抗素水平与hs-CRP水平呈正相关,故抵抗素可能通过炎症机制影响冠状动脉粥样硬化病变的进程。

关键词(KeyWords)： 冠状动脉疾病;绝经后期;血清抵抗素

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 奥德格尔勒·图木尔,韩江莉,毛节明

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