缺血预处理限制心肌梗塞范围的作用与腺苷受体的关系
陈健,张钧华,林静,邱原刚,汪丽蕙
摘要(Abstract)：
本实验采用家兔在体缺血预处理模型(5分钟冠脉阻塞,10分钟再灌注后,30分钟冠脉阻塞,120分钟再灌注),观察了其对心肌梗塞范围的影响以及腺苷受体在缺血预处理机制中的作用.结果表明,缺血预处理可显著降低心肌梗塞范围(14.1%与对照组36.6%比较,P<0.01),而这一效应可被非特异性腺苷受体拮抗剂8-苯基茶碱所阻断(梗塞范围32.1%,P<0.01).提示缺血预处理的心肌保护作用与腺苷受体密切相关.
关键词(KeyWords)： 心肌梗塞;腺苷受体
基金项目(Foundation):
作者(Author): 陈健,张钧华,林静,邱原刚,汪丽蕙
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