张明,赵卓,张建奇,吴熙,张基昌

• 1:吉林大学第二医院心内科

摘要(Abstract)：

<正>心血管疾病尤其是心肌梗死是全球临床死亡的主要原因之一。在过去的几十年中,冠状动脉支架置入术使全世界许多患者受益。然而,目前血管支架存在一定的缺点,尤其是内皮化受损导致支架内血栓形成和新生内膜过度增生。原位内皮化是解决再狭窄及支架内晚期血栓形成最具前景的研究方向。原位内皮化是指在冠状动脉支架置入术后,促进功能性内皮直接再生于支架表面。早期方法主要是吸引支架与血管接触部位的内皮细胞(endothelial cells,ECs),但是较低的ECs迁

关键词(KeyWords)： 原位内皮化;生物活性涂层;支架置入

Abstract:

Keywords:

基金项目(Foundation): 吉林省自然科学基金项目(20160101061JC);; 吉林省教育厅“十三五”科学技术研究项目,吉教科合字[2016]第481号;; 吉林省财政厅[2017]科教字(800)号;; 吉林大学研究生创新基金资助项目(101832018C072);; 吉林省产业技术研究与开发专项项目(2019C047)

作者(Author): 张明,赵卓,张建奇,吴熙,张基昌

参考文献(References)：

• [1]Hristov M,Weber C.Endothelial progenitor cells in vascular repair and remodeling.Pharmacol Res,2008,58(2):148-151.
• [2]Eichmann A,Simons M.VEGF signaling inside vascular endothelial cells and beyond.Curr Opin Cell Biol,2012,24(2):188-193.
• [3]Miyazu K,Kawahara D,Ohtake H,et al.Luminal surface design of electrospun small-diameter graft aiming at in situ capture of endothelial progenitor cell.J Biomed Mater Res B Appl Biomater,2010,94(1):53-63.
• [4]Kawahara D,Matsuda T.Hydrodynamic shear-stress-dependent retention of endothelial and endothelial progenitor cells adhered to vascular endothelial growth factor-fixed surfaces.J Biomed Mater Res B Appl Biomater,2012,100(5):1218-1228.
• [5]Takabatake S,Hayashi K,Nakanishi C,et al.Vascular endothelial growth factor-bound stents:application of in situ capture technology of circulating endothelial progenitor cells in porcine coronary model.J Interv Cardiol,2014,27(1):63-72.
• [6]Major TC,Brant DO,Reynolds MM,et al.The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer.Biomaterials,2010,31(10):2736-2745.
• [7]Kushwaha M,Anderson JM,Bosworth CA,et al.A nitric oxide releasing,self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices.Biomaterials,2010,31(7):1502-1508.
• [8]Yang Z,Yang Y,Zhang L,et al.Mussel-inspired catalytic selenocystamine-dopamine coatings for long-term generation of therapeutic gas on cardiovascular stents.Biomaterials,2018,178:1-10.
• [9]Rubin H.Serine protease inhibitors(SERPINS):where mechanism meets medicine.Nat Med,1996,2(6):632-633.
• [10]Beamish JA,Geyer LC,Haq-Siddiqi NA,et al.The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotype.Biomaterials,2009,30(31):6286-6294.
• [11]Yang Z,Tu Q,Wang J,et al.The role of heparin binding surfaces in the direction of endothelial and smooth muscle cell fate and reendothelialization.Biomaterials,2012,33(28):6615-6625.
• [12]Gong F,Cheng X,Wang S,et al.Heparin-immobilized polymers as non-inflammatory and non-thrombogenic coating materials for arsenic trioxide eluting stents.Acta Biomater,2010,6(2):534-546.
• [13]Aoki J,Serruys PW,van Beusekom H,et al.Endothelial progenitor cell capture by stents coated with antibody against CD34:the HEALING-FIM(healthy endothelial accelerated lining inhibits neointimal growth-first in man)registry.J Am Coll Cardiol,2005,45(10):1574-1579.
• [14]Sedaghat A,Sinning JM,Vasa-Nicotera M,et al.The revised Euro SCOREⅡfor the prediction of mortality in patients undergoing transcatheter aortic valve implantation.Clin Res Cardiol,2013,102(11):821-829.
• [15]Wei Y,Ji Y,Xiao LL,et al.Surface engineering of cardiovascular stent with endothelial cell selectivity for in vivo re-endothelialisation.Biomaterials,2013,34(11):2588-2599.
• [16]魏雨,纪璎,肖琳琳,等.具有内皮细胞选择性的细胞膜仿生支架材料的研究.高分子学报,2010,(12):1474-1478.
• [17]Gajbhiye KR,Gajbhiye V,Siddiqui IA,et al.cRGD functionalised nanocarriers for targeted delivery of bioactives.J Drug Target,2018,23:1-14.
• [18]Boateng SY,Lateef SS,Mosley W,et al.RGD and YIGSRsynthetic peptides facilitate cellular adhesion identical to that of laminin and fibronectin but alter the physiology of neonatal cardiac myocytes.Am J Physiol Cell Physiol,2005,288(1):C30-C38.
• [19]Larsen CC,Kligman F,Tang C,et al.A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesion.Biomaterials,2007,28(24):3537-3548.
• [20]Jayasena SD.Aptamers:an emerging class of molecules that rival antibodies in diagnostics.Clin Chem,1999,45(9):1628-1650.
• [21]Hoffmann J,Paul A,Harwardt M,et al.Immobilized DNAaptamers used as potent attractors for porcine endothelial precursor cells.J Biomed Mater Res A,2008,84(3):614-621.
• [22]Hoffmann J,Groll J,Heuts J,et al.Blood cell and plasma protein repellent properties of star-PEG-modified surfaces.J Biomater Sci Polym Ed,2006,17(9):985-996.
• [23]Rotmans JI,Heyligers JM,Verhagen HJ,et al.In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyperplasia in porcine arteriovenous expanded polytetrafluoroethylene grafts.Circulation,2005,112(1):12-18.
• [24]Avci-Adali M,Steinle H,Michel T,et al.Potential capacity of aptamers to trigger immune activation in human blood.PLoS One,2013,8(7):e68810.
• [25]Bull E,Madani SY,Sheth R,et al.Stem cell tracking using iron oxide nanoparticles.Int J Nanomedicine,2014,9:1641-1653.
• [26]Kyrtatos PG,Lehtolainen P,Junemann-Ramirez M,et al.Magnetic tagging increases delivery of circulating progenitors in vascular injury.JACC Cardiovasc Interv,2009,2(8):794-802.