经皮穿刺旋磨动脉内膜促动脉自闭动物实验The experiment of promoting occlusion of the arteries by rotating atery intima
侯传举,张端珍,王琦光,崔春生,匡丽,陈兵,汪洋
摘要(Abstract)：
目的为应用新方法治疗动脉导管未闭(PDA)提供实验数据和间接证据。方法 11条实验犬,犬龄为14～20个月,(16.7±3.2)个月,体重为20～25kg,(22.7±2.5)kg。经皮穿刺左右腋动脉造影,测量腋动脉内径3.2～4.8mm,(3.9±0.6)mm,选择合适型号旋磨器(在测量动脉直径基础上增加1.0～1.5mm,作为选择旋磨器的标准),旋磨腋动脉内膜,旋磨术后4周再次行腋动脉造影,观察腋动脉内径变化,最后处死实验犬,取左右腋动脉行病理检查。结果旋磨22条腋动脉均有不同程度变化,其中8条动脉完全闭合,12条动脉内径不同程度狭窄,其中4条动脉比旋磨术前狭窄≥2/3,4条动脉比旋磨术前狭窄1/2,4条动脉比旋磨术前狭窄1/3,闭合率为36.4%,总有效率为90.9%。另外2条动脉比旋磨术前狭窄<1/3,视为无效。结论经皮穿刺旋磨动脉内膜,可促动脉自闭,为应用新方法治疗PDA提供了实验数据和间接证据。
关键词(KeyWords)： 穿刺术;旋磨动脉内膜;动脉导管未闭;狗
基金项目(Foundation): 国家自然科学基金资助(30972956)
作者(Author): 侯传举,张端珍,王琦光,崔春生,匡丽,陈兵,汪洋
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