王秀,马依彤,杨毅宁,李晓梅,李东泽

• 1:新疆医科大学第一附属医院心脏中心

摘要(Abstract)：

目的探讨继发孔型房间隔缺损相关性肺动脉高压(ASD-PAH)与血小板活化标志物平均血小板体积(MPV)的关系及其影响因素。方法纳入2010年1月至2014年3月就诊于新疆医科大学第一附属医院心脏中心行介入治疗的先天性心脏病(CHD)患者中继发孔型ASD患者627例作为ASD组,根据有无PAH再分为无PAH组207例,PAH组420例;选择同时间段就诊于新疆医科大学第一附属医院体检中心的690例健康人群作为对照组。所有患者均进行血细胞参数检查、生化检查、心电图检查等,其中继发孔型ASD组患者均行右心导管检查。结果继发孔型ASD组MPV值较对照组高[(9.4±1.6)fl比(8.9±1.5)fl,P<0.001],在ASD患者亚组间比较,MPV值的差异无统计学意义(P=0.268)。ASD-PAH独立影响因素的Logistic回归分析显示,年龄(每10年,OR1.401,95%CI 1.087~1.806,P=0.009)、右心室舒张末期内径(OR 1.101,95%CI 1.026~1.181,P=0.008)、ASD直径(OR 1.064,95%CI 1.013~1.118,P=0.013)是继发孔型ASD-PAH的独立危险因素。结论年龄、右心室舒张末期内径、ASD直径是影响继发孔型ASD发生、发展的相关因素。PAH患者中存在血小板活化,而血小板活化可能不是影响PAH发生、发展的直接原因。

关键词(KeyWords)： 房间隔缺损;肺动脉高压;平均血小板体积

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王秀,马依彤,杨毅宁,李晓梅,李东泽

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