心包腔内注射尿激酶对实验性缩窄性心包炎的防治作用Preventing Effect of Intrapericardial Injection of Urokinase on Experimental Constrictive Pericarditis
刘键,张永东,张纪云,吴佳学,潘惠麟,侯子山,李瑞杰
摘要(Abstract)：
将刺激合剂注入犬心包腔内使其形成实验性渗出性心包炎,然后分别将尿激酶(UK,4×10000U,治疗组,n=10)和生理盐水(对照组,n=11)注入犬心包腔内.结果,治疗组中UK能显著地降低心包渗出液中纤维蛋白原(Fib)含量(1.91±0.9vs2.6±1.11g/l,P<0.05).病理检查证实,对照组的11只犬全部形成了缩窄性心包炎,治疗组中仅有2只犬发生了心包粘连,两组粘连的发生率有非常显著的差异(20%vs100%、P<0.005).治疗组心包壁层的厚度显著地低于对照组(0.38±0.06vs0.66±0.10mm,P<0.001).用药期间血液中Fib水平(4.51±1.40vs3.85±0.78g/l)、白陶土部分凝血活酶时间(34.81±3.98vs36.40±5.10秒)和凝血酶时间(1.75±1.49vs16.31±1.10秒)均无显著变化(P>0.05).以上结果提示,UK可通过增强心包腔内局部的纤溶活性而防止心包粘连的形成.
关键词(KeyWords)： 犬缩窄性心包炎;纤维蛋白原;尿激酶
基金项目(Foundation): 山东省卫生厅资助课题
作者(Author): 刘键,张永东,张纪云,吴佳学,潘惠麟,侯子山,李瑞杰
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