冠状动脉内多普勒超声评价猪急性冠状动脉闭塞侧支循环状态及影响因素Evaluation of coronary collateral circulation with intracoronary Doppler ultrasound after acute occlusion in pigs
徐晤,张超群,吴建东,王志荣,夏勇,李东野
摘要(Abstract)：
目的评价猪急性闭塞冠状动脉侧支循环状态及硝酸甘油和酚妥拉明对其的影响。方法使用冠状动脉内多普勒超声测定14头小型家猪正常状态及急性闭塞后左回旋支的血流频谱,并观察冠状动脉内应用硝酸甘油和酚妥拉明对其的影响。结果急性闭塞10min时回旋支远端的平均峰值流速(APV)明显低于正常(0.97±1.05cm/s比25.78±4.36cm/s,P<0.01),应用硝酸甘油和酚妥拉明后梗死相关血管变为反向或双向血流,APV绝对值(8.32±1.53cm/s和8.54±2.15cm/s)较用药前明显增加(P<0.01);闭塞后90min时及重复应用上述两药后APV分别为0.99±1.14cm/s、9.02±1.47cm/s和8.95±2.36cm/s,闭塞90min较闭塞即刻差异无统计学意义,用两药后APV值差异无统计学意义(P均>0.05)。结论猪急性冠状动脉闭塞时侧支循环自身建立不足,硝酸甘油和酚妥拉明均可明显增加冠状动脉侧支循环血流。
关键词(KeyWords)： 冠状动脉疾病;超声心动描记术,多普勒,彩色;侧支循环;猪,雏型
基金项目(Foundation):
作者(Author): 徐晤,张超群,吴建东,王志荣,夏勇,李东野
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