张磊,韩雅玲,荆全民,王效增,李毅,张权宇,李晶,霍勇,张岩

• 1:沈阳军区总医院心内科
• 2:北京大学第一医院

摘要(Abstract)：

目的探讨不同程度肾功能降低患者的冠心病发病率及其冠状动脉病变的严重程度。方法收集9608例行诊断性冠状动脉造影疑诊冠心病的患者进行回顾性分析,依据适合中国人的改良MDRD方程估算的肾小球滤过率(eGFR)水平将患者分为肾功能正常(>90ml·min-1.1.73m-2)、轻度降低(60～89ml·min-1.1.73m-2)、中度降低(30～59ml·min-1.1.73m-2)和重度降低(<29ml·min-1.1.73m-2)4组,探讨不同程度肾功能损害患者的冠心病发病率及其冠状动脉狭窄的严重程度。结果 9608例患者中存在肾功能降低(eGFR<90ml·min-1.1.73m-2)者4939例,占51.4%。肾功能降低组患者冠心病发病率显著高于肾功能正常组(55.7%比44.3%,P<0.001),且冠状动脉狭窄程度更为严重,表现为患者病变支数更多(1.38±1.13比1.06±1.08,P<0.001)、Gensini积分更高(29.36±35.53比21.32±30.30,P<0.001)。肾功能正常组与轻度、中度、重度降低组患者冠心病的发病率分别为59.7%、69.4%、79.1%、92.3%,冠心病发病率随肾功能降低的程度而明显增高(P<0.001)。线性回归分析显示:Gensini积分与慢性肾病(Chronic kidney disease,CKD)分期(β=0.061,OR值3.219,95%CI:2.075～4.364,P<0.001)呈独立正相关。Logistic回归分析证实:CKD与冠心病诊断存在显著关联(OR值1.330,95%CI:1.177～1.503,P<0.001)。结论肾功能降低患者的冠心病发病率明显升高,且其冠状动脉狭窄程度更为严重;患者肾功能降低越显著,则冠心病发病率越高;肾功能降低与冠状动脉狭窄程度呈独立正相关;CKD与冠心病发生存在显著关联。

关键词(KeyWords)： 动脉粥样硬化;冠心病;肾功能不全

Abstract:

Keywords:

基金项目(Foundation): 十一五国家科技支撑计划(2006BAI01A02)

作者(Author): 张磊,韩雅玲,荆全民,王效增,李毅,张权宇,李晶,霍勇,张岩

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