球囊损伤对兔颈动脉平滑肌bFGF基因表达的影响The gene expression of bFGF in rabbit's careries after injury
赖金川,戴红源,李庚山,许家琍,蒋锡嘉,尹丽娅
摘要(Abstract)：
在经皮冠状动脉腔内成形术（PTCA）后再狭窄的发病机制中，生长因子因刺激中膜平滑肌细胞增生而发挥了重要作用。碱性成纤维细胞生长因子（bFGF）是一种强效的促分裂因子，为证实球囊损伤是否刺激了碱性成纤维细胞生长因子的基因表达，本实验采用Northernblot方法，以bFGF的cDNA探针与兔颈动脉球囊损伤后的颈动脉中膜平滑肌总RNA杂交。结果显示，颈动脉损伤后其平滑肌中的bFGFmRNA水平低于对照组。从而表明bFGF在再狭窄的发病机制中并不是主要的作用因子。
关键词(KeyWords)： 动脉成形术;再狭窄;碱性成纤维细胞生长因子
基金项目(Foundation):
作者(Author): 赖金川,戴红源,李庚山,许家琍,蒋锡嘉,尹丽娅
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